Disruption of E2F signaling suppresses the INK4a-induced proliferative defect in M33-deficient mice

Oncogene
Nathalie CoréMalek Djabali

Abstract

Polycomb group (Pc-G) proteins associate to form large complexes that repress Hox genes, thereby imposing Hox gene expression pattern required for development. However, Pc-G proteins have a Hox-independent function in controlling cell proliferation. Here we show that embryonic fibroblasts derived from M33-deficient mice are impaired in the progression into the S phase of the cell cycle, as shown by a reduced rate of incorporation of bromodeoxyuridine. These cells have a senescent phenotype, associated to an abnormal accumulation of the cyclin-dependent kinase inhibitor p16INK4a protein. We demonstrate that this defect is bypassed in mutant embryonic fibroblasts expressing a transdominant negative form of the cell cycle controlling transcription factor E2F (E2F-DB). In addition, we show that the polycomb protein M33 controls critical expansion of B- and T-lymphocyte precursors. Together, our results emphasize M33-Polycomb protein function in cell cycle control.

References

Apr 1, 1991·Current Opinion in Immunology·R Scollay
May 1, 1991·The Journal of Experimental Medicine·R R HardyK Hayakawa
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A StrasserA W Harris
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Aug 1, 1995·Current Opinion in Genetics & Development·V Pirrotta
May 1, 1995·The Journal of Experimental Medicine·B LucasC Penit
Nov 1, 1993·Immunology Today·D I Godfrey, A Zlotnik
Aug 1, 1997·Current Opinion in Genetics & Development·A Gould
Oct 5, 2001·Molecular Cell·A DahiyaD C Dean
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·C J Sherr
Mar 20, 2002·The Journal of Experimental Medicine·Hideaki OhtaYoshihiro Takihara
Dec 1, 1981·Applied Biochemistry and Biotechnology·A RembaumH L Heyneker

❮ Previous
Next ❯

Citations

Aug 22, 2006·Nature Reviews. Molecular Cell Biology·Jesús Gil, Gordon Peters
Jan 19, 2012·Biologie aujourd'hui·Adrienne BailletCorinne Cotinot
Jun 21, 2005·Genes & Development·Sophia W M BruggemanMaarten van Lohuizen
Feb 16, 2016·Clinical Epigenetics·Pier-Luc ClermontCheryl D Helgason
Dec 18, 2010·Cytokine·Michael J Shapiro, Virginia Smith Shapiro
Dec 14, 2007·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Jun MikiTakehiko Kamijo
May 9, 2007·Molecular Reproduction and Development·Nancy T Ruddock-D'CruzMichael K Holland
May 6, 2014·Journal of Zhejiang University. Science. B·Rong-gang MaBo Cheng
Jun 9, 2015·Oncogene·M Koppens, M van Lohuizen
Jan 15, 2017·Experimental Hematology·Miguel Vidal, Katarzina Starowicz
Nov 26, 2004·The Journal of Biological Chemistry·Jan Willem VonckenUlf R Rapp
Nov 15, 2007·Cytogenetic and Genome Research·K MiharaA Kimura
Dec 22, 2011·Endocrinology·Yuko Katoh-FukuiKen-ichirou Morohashi
Sep 2, 2020·The Journal of Cell Biology·Claudia BaumannRabindranath De La Fuente
Aug 28, 2020·Scientific Reports·Zhiyuan V ZouPer Lindahl
Oct 11, 2017·Journal of Biochemistry·Takayuki KawaguchiJun-Ichi Nakayama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.