Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN

Molecular and Cellular Neurosciences
Kimberly J ChristieD W Zochodne

Abstract

Exploiting molecules and pathways important in developmental axon behaviour may offer new insights into regenerative behaviour of adult peripheral neurons after injury. In previous work, we have provided evidence that inhibition or knockdown of PTEN (phosphatase and tensin homolog deleted on chromosome ten) dramatically increases adult peripheral axon outgrowth, especially in preconditioned neurons (Christie et al., 2010). PTEN appears to operate as an endogenous brake to regeneration. Recent reports from Drinjakovic et al. (2010) have highlighted a role for the ubiquitin proteasome system (UPS) during neurite outgrowth in developing Xenopus retinal ganglion cells. Specifically, disruption of the UPS E3 ligase Nedd4 (neural precursor cell-expressed developmentally down-regulated protein 4) inhibited neurite branching through up-regulation of PTEN. We explored the potential role of Nedd4 in the peripheral neurons of adult rat dorsal root ganglia (DRG), particularly its impact on regenerative behaviour. Global inhibition of the UPS in vitro was associated with a severe decrease in neurite branching, both in preconditioned (injured) and control DRG sensory neurons. These involved neurons however maintained or qualitatively increas...Continue Reading

References

Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·David C WhitemanCharis Eng
Dec 4, 2003·Journal of Neuroscience Research·Heike LaserMichael P Coleman
Jan 23, 2004·PLoS Biology·Michael H Glickman, Noam Adir
Jan 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Poonam VermaJames W Fawcett
Jul 27, 2005·Journal of Neuropathology and Experimental Neurology·Yuan Yuan ChenDouglas W Zochodne
Jan 16, 2007·Cell·Xinjiang WangXuejun Jiang
Mar 3, 2007·Pharmacological Reviews·Jason J Yi, Michael D Ehlers
Mar 21, 2007·Biochemical Society Transactions·K E Cosker, B J Eickholt
Jun 2, 2007·Developmental Biology·Doyeob Kim, Gregory R Dressler
Jun 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Fatemeh FouladkouDaniela Rotin
Oct 22, 2008·The International Journal of Biochemistry & Cell Biology·Eun Joo SongYoung Sook Yoo
Apr 22, 2009·Cell·Masahiro NarimatsuJeffrey L Wrana
Jun 9, 2009·Cellular and Molecular Life Sciences : CMLS·Danielle E Read, Adrienne M Gorman
Sep 12, 2009·The Journal of Biological Chemistry·Jacqueline R E LeeDavid J Katzmann
Sep 22, 2009·Nature Cell Biology·Michiel T van DiepenBritta J Eickholt
Jan 27, 2010·The Journal of Biological Chemistry·Young-Don KwakFrancesca-Fang Liao
Feb 18, 2010·Neuron·Jovana DrinjakovicChristine E Holt
Jul 9, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kimberly J ChristieDouglas W Zochodne
Nov 12, 2010·Molecular Neurodegeneration·Young-Don KwakFrancesca-Fang Liao
Feb 23, 2011·Journal of Neurochemistry·Amy LinHeng-Ye Man

❮ Previous
Next ❯

Citations

Aug 27, 2013·Current Genetics·José Miguel MuletLynne Yenush
Apr 13, 2013·Trends in Cell Biology·Adam Naguib, Lloyd C Trotman
Sep 21, 2013·Neural Development·Michael J SchmeisserTobias M Boeckers
Mar 12, 2013·Neural Plasticity·Andrew M Hamilton, Karen Zito
Aug 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Hung-En HsiaHiroshi Kawabe
May 17, 2015·FEBS Letters·Mateusz Cyryl Ambrozkiewicz, Hiroshi Kawabe
Jul 16, 2015·The European Journal of Neuroscience·Anand KrishnanDouglas W Zochodne
Dec 21, 2014·Gene·Natasha Anne Boase, Sharad Kumar
Jul 27, 2015·Experimental Neurology·Jose A MartinezDouglas W Zochodne
Mar 19, 2013·Neuroscience·K J Christie, D Zochodne
Apr 15, 2014·Current Opinion in Neurobiology·Yi LuZhigang He
May 27, 2014·Frontiers in Molecular Neuroscience·Biliana O Veleva-Rotse, Anthony P Barnes
Jan 21, 2017·Developmental Biology·Lena-Maria KiemSusanne J Kühl
Feb 11, 2020·Frontiers in Cellular Neuroscience·Sataporn JamsuwanBarbara Hausott
May 13, 2014·Nature Structural & Molecular Biology·Yuji ShiXuejun Jiang
Nov 23, 2019·Brain : a Journal of Neurology·Krish ChandrasekaranJames W Russell
Aug 21, 2019·Cold Spring Harbor Perspectives in Medicine·Sebastian Rademacher, Britta J Eickholt
Feb 15, 2017·The Journal of Cell Biology·Muhan ChenLloyd C Trotman

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.