May 20, 2016

Disruption of human astn2 function by ZIKV ns4b gene as a molecular basis for Zika viral microcephaly

BioRxiv : the Preprint Server for Biology
Bhaskar Ganguly, Enakshi Ganguly


The present Zika virus (ZIKV) pandemic is being associated with increased incidence of microcephaly in newborns. However, a molecular basis for such pathogenesis is distinctly lacking. Comparative nucleic acid sequence analysis showed similarity between regions of non-structural protein 4B (ns4b) gene of ZIKV and human astrotactin2 (astn2) gene. Based on these findings, a molecular target of Zika viral microcephaly is being proposed.

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Mentioned in this Paper

Pathogenic Aspects
NS4B protein, hepatitis C virus
Viral Structural Proteins
Molecular Target

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