Disruption of imprinting caused by deletion of the H19 gene region in mice

Nature
P A LeightonS M Tilghman

Abstract

The imprinted H19 gene, which encodes an untranslated RNA, lies at the end of a cluster of imprinted genes in the mouse. Imprinting of the insulin-2 and insulin-like growth factor 2 genes, which lie about 100 kilobases upstream of H19, can be disrupted by maternal inheritance of a targeted deletion of the H19 gene and its flanking sequence. Animals inheriting the H19 mutation from their mothers are 27% heavier than those inheriting it from their fathers. Paternal inheritance of the disruption has no effect, which presumably reflects the normally silent state of the paternal gene. The somatic overgrowth of heterozygotes for the maternal deletion is attributed to a gain of function of insulin-like growth factor 2, rather than a loss of function of H19.

References

Jan 1, 1990·Molecular and Cellular Biology·C I BrannanS M Tilghman
May 9, 1991·Nature·M S BartolomeiS M Tilghman
Oct 25, 1991·Nucleic Acids Research·M W McBurneyK Jardine
Feb 22, 1991·Cell·T M DeChiaraA Efstratiadis
Jun 1, 1991·Genes & Development·M E Brunkow, S M Tilghman
Nov 1, 1988·Molecular and Cellular Biology·H Yoo-WarrenS M Tilghman
Jan 1, 1988·Annual Review of Genetics·D Solter
Oct 7, 1988·Cell·O R Choi, J D Engel
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Jun 1, 1980·European Journal of Biochemistry·C Auffray, F Rougeon
Aug 15, 1994·Genes & Development·K Pfeifer, S M Tilghman
Sep 1, 1993·Genes & Development·M S BartolomeiS M Tilghman
Oct 21, 1993·Nature·Y HaoB Tycko
Apr 1, 1995·Nature Genetics·K D TremblayM S Bartolomei
Jul 1, 1994·Nature Genetics·T MoultonB Tycko
Apr 1, 1994·Current Opinion in Genetics & Development·A Efstratiadis
Sep 22, 1994·Nature·F GuillemotA L Joyner
Nov 25, 1993·Nature·E LiR Jaenisch
Jun 1, 1993·Human Molecular Genetics·B D HendrichH F Willard
Apr 22, 1993·Nature·A C Ferguson-SmithM A Surani

❮ Previous
Next ❯

Citations

Dec 16, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M PellegriniA Forabosco
Feb 6, 1998·Journal of Neuroscience Research·S W HettsR L Mozell
Nov 20, 1997·Journal of Cellular Physiology·K J McLaughlinJ Mann
Feb 27, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K Nakayama, K Nakayama
Oct 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Viville, M A Surani
Jan 11, 2005·The Journal of Pathology·E FoulstoneA B Hassan
Sep 25, 2001·The Journal of Pathology·M Paulsen, A C Ferguson-Smith
Aug 28, 1999·Molecular Biotechnology·J M Greally
Oct 8, 2008·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Paulo P Amaral, John S Mattick
Apr 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C V BeecheyJ Jones
Sep 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·W TangD H Chui
Jan 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J M GreallyS Zemel
May 17, 2011·Human Genetics·Clive J PetryDavid B Dunger
Nov 11, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anenisia C AndradeOla Nilsson
Aug 19, 2008·Journal of Human Genetics·Kazuki YamazawaTsutomu Ogata
Jan 17, 2009·In Vitro Cellular & Developmental Biology. Animal·Anne S JürgensJürgen S Scheele
Apr 20, 2004·Journal of Hepatology·Youhei YamamotoKatsuhiko Enomoto
Jun 19, 2004·Genomics·Raluca I Verona, Marisa S Bartolomei
Jan 1, 1996·Placenta·G C FranklinR Ohlsson
Dec 21, 2002·Trends in Genetics : TIG·Katharine L Arney
Aug 1, 1997·Trends in Genetics : TIG·R Jaenisch
Aug 1, 1997·Trends in Genetics : TIG·W Reik, E R Maher
Jan 10, 1998·Trends in Genetics : TIG·L D Hurst, G T McVean
Apr 28, 1999·Trends in Genetics : TIG·L D Hurst, N G Smith
Jul 31, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·V TanosI Ariel
Mar 4, 1998·Molecular and Cellular Endocrinology·P UngaroA Riccio
Aug 29, 1998·Molecular and Cellular Endocrinology·A Wutz, D P Barlow
Aug 8, 1997·Biochimica Et Biophysica Acta·R Mostoslavsky, Y Bergman
Mar 25, 2000·Endocrinology and Metabolism Clinics of North America·C GicquelX Bertagna
Jun 1, 1996·Current Opinion in Cell Biology·R M John, M A Surani
Sep 12, 2000·Current Opinion in Genetics & Development·I Ben-Porath, H Cedar
Sep 1, 1995·Current Biology : CB·A Balmain
Mar 1, 1997·Current Biology : CB·S U KassA P Wolffe
Jan 14, 2003·Seminars in Cell & Developmental Biology·Jörn Walter, Martina Paulsen
May 12, 1998·Molecular Medicine Today·I M Morison, A E Reeve
Jan 8, 1999·Mutation Research·D J PulfordR L Jirtle
May 22, 2010·The British Journal of Nutrition·Clive J Petry

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.