Disruption of morphine-conditioned place preference by a delta2-opioid receptor antagonist: study of mu-opioid and delta-opioid receptor expression at the synapse.

The European Journal of Neuroscience
Sophie K BillaJosé A Morón

Abstract

The addictive properties of morphine limit its clinical use. Learned associations that develop between the abused opiate and the environment in which it is consumed are engendered through Pavlovian conditioning processes. Disruption of the learned associations between the opiate and environmental cues may be a therapeutic approach to prevent morphine dependence. Although a role for the delta-opioid receptor in the regulation of the rewarding properties of morphine has already been shown, in this study we further characterized the role of the delta-opioid receptor in morphine-induced conditioned responses by examining the effect of a selective delta2-opioid receptor antagonist (naltriben), using a conditioned place preference paradigm in rats. Additionally, we used a subcellular fractionation technique to analyze the synaptic localization of mu-opioid and delta-opioid receptors in the hippocampus, in order to examine the molecular mechanisms that may underlie this morphine-induced conditioned behavior. Our data show that the administration of 1 mg/kg naltriben (but not 0.1 mg/kg) prior to morphine was able to block morphine-induced conditioned place preference. Interestingly, this naltriben-induced disruption of morphine conditi...Continue Reading

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Citations

May 8, 2013·Psychopharmacology·Richard M van RijnJennifer L Whistler
Jun 15, 2013·Pharmacology & Therapeutics·Paul Chu Sin Chung, Brigitte L Kieffer
Apr 12, 2012·Expert Reviews in Molecular Medicine·Cristina M CostantinoLakshmi A Devi
Apr 17, 2012·Addiction Biology·Elliot C NelsonGrant W Montgomery
Sep 26, 2014·Expert Opinion on Drug Discovery·Chris P Bailey, Stephen M Husbands
Oct 27, 2016·Neuroscience·Ana Vicente-SanchezAmynah A Pradhan
Jun 28, 2016·Pharmacological Reviews·Louis GendronGraciela Pineyro
Sep 21, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dana M Nerenberg, Jeffrey Fudin
Mar 29, 2014·British Journal of Pharmacology·Louis GendronWendy Walwyn
Nov 22, 2016·Journal of Neuroscience Research·Helen E Scharfman, Neil J MacLusky
Jul 12, 2020·International Journal of Molecular Sciences·Rana El RawasAlex Hofer
Nov 3, 2020·Frontiers in Behavioral Neuroscience·Greer McKendrick, Nicholas M Graziane

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