PMID: 2501717Apr 24, 1989Paper

Disruption of muscarinic receptor-G protein coupling is a general property of liquid volatile anesthetics

Neuroscience Letters
B L AnthonyR S Aronstam

Abstract

The influences of 3 volatile anesthetics, chloroform, enflurane and isoflurane, on muscarinic acetylcholine receptors in rat brainstem were determined. Each of the volatile anesthetics increased [3H]methylscopolamine [( 3H]MS) binding affinity, but did not affect the number of [3H]MS binding sites. Carbamylcholine affinity for brainstem muscarinic receptors was not altered after equilibration of brainstem membranes with any of these anesthetics. The ability of guanine nucleotides to depress the high affinity binding of two agonists, carbamylcholine and [3H]oxotremorine-M, was decreased or eliminated after equilibration of brainstem membranes with any of the anesthetics. In each of these actions, these anesthetics resemble halothane and diethyl ether. These results indicate that interference with muscarinic receptor-G protein interactions is a common property of liquid volatile anesthetics and may represent a general mechanism for the disruption of signal transmission between cells during anesthesia.

Citations

Oct 27, 2012·Journal of Anesthesia·Kouichiro Minami, Yasuhito Uezono
Jul 15, 1990·Biochemical Pharmacology·B L AnthonyR S Aronstam
Jan 1, 1991·Annals of the New York Academy of Sciences·E PuilK G Baimbridge
Jan 1, 1991·Annals of the New York Academy of Sciences·M Maze, J W Regan
Dec 29, 2010·Biochemistry Research International·Benjamin J PietersNorbert W Seidler
Oct 27, 2005·Anesthesiology·Markus W HollmannMarcel E Durieux
Feb 28, 2001·Anesthesia and Analgesia·M HanazakiD O Warner
Jan 5, 2002·Anesthesia and Analgesia·Michiaki YamakageAkiyoshi Namiki
Aug 7, 2004·The Journal of Pharmacology and Experimental Therapeutics·Masataka KurodaFumio Goto
Oct 8, 1997·The American Journal of Physiology·D O WarnerC M Pabelick
Feb 24, 2006·Pharmacogenetics and Genomics·Jonathan Z PanMaryellen Fazen Eckenhoff
Aug 14, 2002·British Journal of Anaesthesia·M J Rebecchi, S N Pentyala

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