Disruption of neuronal CXCR4 function by opioids: preliminary evidence of ferritin heavy chain as a potential etiological agent in neuroAIDS.

Journal of Neuroimmunology
Jonathan PitcherOlimpia Meucci

Abstract

The chemokine CXCL12 and its receptor, CXCR4, regulate neuronal migration, differentiation, and survival. Alterations of CXCL12/CXCR4 signaling are implicated in different neuropathologies, including the neurological complications of HIV infection. Opiates are important co-factors for progression to neuroAIDS and can disrupt the CXCL12/CXCR4 axis in vitro and in vivo. This paper will review recently identified mechanisms of opiate-induced CXCR4 impairment in neurons and introduce results from pilot studies in human brain tissue, which highlight the role of the protein ferritin heavy chain in HIV neuropathology in patients with history of drug abuse.

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Citations

Apr 6, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Anna Cook Abt, Olimpia Meucci
Jul 13, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Veera Venkata Ratnam BandaruNorman J Haughey
Jan 10, 2014·The Journal of Clinical Investigation·Jonathan PitcherOlimpia Meucci
Mar 5, 2013·Progress in Neurobiology·Annabelle Réaux-Le GoazigoStéphane Mélik Parsadaniantz
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Bo ShenXin-En Huang
Feb 23, 2020·Frontiers in Immunology·Thomas J Rogers
Nov 3, 2011·Journal of Proteome Research·Maddalena Di SanzoMaria Concetta Faniello

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