Disruption of normal iron homeostasis after bronchial instillation of an iron-containing particle

The American Journal of Physiology
Andrew J GhioR B Devlin

Abstract

The atmosphere constitutes a prime vehicle for the movement and redistribution of metals. Metal exposure can be associated with an oxidative stress. We tested the hypothesis that, in response to an iron-containing particle, the human respiratory tract will demonstrate an increased expression of both lactoferrin and ferritin as the host attempts to transport and store the metal in a chemically less-reactive form and therefore diminish the oxidative stress the particle presents. Subjects (n = 22) were instilled with 20 ml of saline and 20 ml of an iron-containing particle suspended in saline in a right middle lobe bronchus and a lingular bronchus, respectively. At either 1, 2, or 4 days after this exposure, the volunteer was lavaged for a sample of the lower respiratory tract, and concentrations of L-ferritin, transferrin, and lactoferrin were measured by enzyme immunoassay, immunoprecipitin analysis, and enzyme-linked immunosorbent assay (ELISA), respectively. Transferrin receptor was also quantified by ELISA. The concentrations of L-ferritin in the lavage fluid of lung exposed to particles were significantly increased relative to the levels of the protein in the segment exposed to saline. Relative to saline instillation, transf...Continue Reading

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Citations

Jun 7, 2003·American Journal of Respiratory Cell and Molecular Biology·Andrew J GhioClaude A Piantadosi
Jan 17, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ciara M ShaverJulie A Bastarache
Jan 6, 2019·Pharmaceuticals·Joana NevesMartina U Muckenthaler
Dec 7, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna L LaganGregory J Quinlan
Sep 11, 2012·Journal of Clinical Biochemistry and Nutrition·Yasumasa OkazakiShinya Toyokuni
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·A J GhioF Yang

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