PMID: 6540617Jul 30, 1984Paper

Disruption of ongoing maternal responsiveness in rats by central administration of morphine sulfate

Brain Research
B S Rubin, R S Bridges

Abstract

The ability of central morphine administration to disrupt established maternal responsiveness in rats was examined. Studies focused on the direct administration of morphine sulfate (M) to the preoptic area (POA), a region known to be involved in the expression of maternal behavior in this species. In the first experiment, crystalline M was administered via bilateral 28 g cannulae to the POA or ventromedial hypothalamus (VMH) of 31 ovariectomized, estrogen-primed, nulliparous, pup-induced, maternal females. All subjects were tested twice for maternal responsiveness; once after M-filled cannulae and once after blank inserts were lowered into place. Behavioral tests lasted for 1 h after foster young were introduced into the test cage, and retrieval, grouping and crouching responses were recorded. Thirteen of 14 females with cannulae placements in the POA showed disruption of maternal responsiveness following morphine treatment. In contrast, only 4 of 17 females with VMH implants showed some deficit in maternal behavior following opiate administration. Results of a second experiment established that M-filled implants placed in the POA of lactating females were capable of disrupting the responsiveness of nursing females toward their...Continue Reading

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Citations

Sep 21, 2012·Psychopharmacology·Francesca R D'Amato, Flaminia Pavone
Nov 1, 1986·Pharmacology, Biochemistry, and Behavior·C H Kinsley, R S Bridges
May 1, 1988·Pharmacology, Biochemistry, and Behavior·C H KinsleyR S Bridges
Sep 1, 1989·Pharmacology, Biochemistry, and Behavior·P E MannR S Bridges
May 1, 1991·Pharmacology, Biochemistry, and Behavior·L F FelicioR S Bridges
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·C H Kinsley
Jan 1, 1988·Psychoneuroendocrinology·M Numan
Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·C M Miranda-Paiva, L F Felicio
Jan 1, 1991·Neuroscience and Biobehavioral Reviews·M B Kristal
Aug 14, 1999·Brain Research. Developmental Brain Research·P E MannR S Bridges
Feb 17, 2000·Brain Research. Developmental Brain Research·C C GulledgeR P Hammer
Jun 19, 2001·Psychoneuroendocrinology·R SlamberováI Vathy
Sep 7, 2001·Brain Research Bulletin·C M Miranda-PaivaL F Felicio
Aug 26, 2000·Behavioral Neuroscience·E M Byrnes, R S Bridges
Dec 16, 2004·Behavioral Neuroscience·N Popeski, B Woodside
May 29, 2012·Ecology of Food and Nutrition·Mark B KristalAlexis C Thompson
Feb 1, 1993·Journal of Neuroendocrinology·S M LuckmanR J Bicknell
Jun 1, 1994·Scandinavian Journal of Psychology·K Larsson
Jan 15, 1997·Annals of the New York Academy of Sciences·G J De Vries, C Villalba
Jun 24, 2011·Journal of Neuroendocrinology·M H SukikaraL F Felicio
Aug 13, 2003·The European Journal of Neuroscience·Cláudia M Miranda-PaivaLuciano F Felicio
Dec 17, 2014·Frontiers in Neuroendocrinology·Robert S Bridges
Apr 4, 2017·British Journal of Pharmacology·Lucie P PellissierJulie Le Merrer
Aug 31, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L M MouraL F Felicio
Oct 28, 2005·Behavioral and Cognitive Neuroscience Reviews·Stephen C Gammie

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