Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease.

Journal of Neural Transmission
Kazunori AdachiNoriaki Koshikawa

Abstract

While motor disturbance in Parkinson's disease can affect innate, programmed processes, such as masticatory mandibular movements, the pathophysiology of such abnormalities remains unclear. This study applies digital analysis by high-speed video signal processing that tracks three dots placed around the mouth for recording masticatory movements in unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. The system analyzes displacement, velocity and cycle duration of the topography of mandibular movement during mastication of sweet potato slices. In monkeys receiving MPTP into the right carotid artery (n = 3), positron emission tomography indicated significant reduction in the binding of (E)-N-(3-iodoprop-2-enyl)-2β-carbo[(11)C]methoxy-3β-(4-methylphenyl)nortropane ([(11)C]PE2I) to the dopamine transporter in the right caudate, putamen, nucleus accumbens and substantia nigra relative to the contralateral hemisphere. These monkeys showed hypokinesia of the left forelimbs and hindlimbs. During mastication, MPTP-treated monkeys chewed preferentially on the left side, while untreated monkeys (n = 3) showed no preference for chewing side. The amplitude of vertical opening and closing movements was reduced in MP...Continue Reading

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Citations

May 14, 1999·Drug Discovery Today·K J Moore
Jun 14, 2016·Clinical Oral Investigations·Giselle Rodrigues RibeiroRenata Cunha Matheus Rodrigues Garcia
Mar 31, 2017·Journal of Neural Transmission·Javier BlesaJosé A Obeso
Jul 20, 2018·Journal of Oral Rehabilitation·Merel C VerhoeffMichail Koutris

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