Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons

Science
D W SretavanL F Reichardt

Abstract

Mouse retinal ganglion cell axons growing from the eye encounter embryonic neurons at the future site of the optic chiasm. After in vivo ablation of these chiasm neurons with a monoclonal antibody and complement, retinal axons did not cross the midline and stalled at approximately the entry site into the chiasm region. Thus, in the mouse, the presence of early-generated neurons that reside at the site of the future chiasm is required for formation of the optic chiasm by retinal ganglion cell axons.

References

Mar 1, 1990·Developmental Biology·J Drazba, V Lemmon
Feb 17, 1994·Nature·R W WilliamsP E Garraghty
Jun 18, 1993·Cell·D V VactorC S Goodman

❮ Previous
Next ❯

Citations

Dec 31, 2002·Brain Research. Brain Research Reviews·Tadashi HamasakiYukitaka Ushio
Mar 8, 2000·Progress in Neurobiology·P Bovolenta, I Fernaud-Espinosa
Oct 16, 2002·Brain Research Bulletin·Davide ViggianoCosimo Passiatore
Feb 7, 1998·Current Opinion in Neurobiology·C A Mason, D W Sretavan
May 6, 1998·Current Opinion in Neurobiology·E T Stoeckli, L T Landmesser
Nov 1, 1995·Visual Neuroscience·M Schütte
Mar 21, 2009·Nature Reviews. Neuroscience·Daniel L ChaoKang Shen
May 14, 2010·Cold Spring Harbor Perspectives in Biology·Alain Chédotal, Linda J Richards
Jun 5, 1998·The British Journal of Ophthalmology·S M CardenW V Good
Apr 12, 2002·Glia·Larry S ShermanCharles Kuntz
Sep 5, 2002·The Journal of Comparative Neurology·Erik Runko, Zaven Kaprielian
Jul 3, 2010·Science China. Life Sciences·XiaoBing Yuan
Dec 8, 2007·Trends in Neurosciences·Larry S Sherman, Stephen A Back
Jul 20, 2005·Progress in Retinal and Eye Research·Glen Jeffery, Lynda Erskine
May 17, 2006·Neuron·Scott E WilliamsTakeshi Sakurai
Dec 17, 2014·ASN Neuro·Lynda Erskine, Eloisa Herrera
Dec 3, 2016·Developmental Neurobiology·Delphine S Prieur, Alexandra Rebsam
May 10, 2019·Journal of Anatomy·Marko Culjat, Nataša Jovanov Milošević
Oct 27, 2015·Neural Development·Paolo PanzaChristian Söllner
Oct 4, 2020·BMC Evolutionary Biology·R G LoosemoreT C Stanger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.