Dec 4, 2012

Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis

Biochimica Et Biophysica Acta
Masanori ItoSatomi Adachi-Akahane

Abstract

STARD10, a member of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) protein family, is highly expressed in the liver and has been shown to transfer phosphatidylcholine. Therefore it has been assumed that STARD10 may function in the secretion of phospholipids into the bile. To help elucidate the physiological role of STARD10, we produced Stard10 knockout mice (Stard10(-/-)) and studied their phenotype. Neither liver content nor biliary secretion of phosphatidylcholine was altered in Stard10(-/-) mice. Unexpectedly, the biliary secretion of bile acids from the liver and the level of taurine-conjugated bile acids in the bile were significantly higher in Stard10(-/-) mice than wild type (WT) mice. In contrast, the levels of the secondary bile acids were lower in the liver of Stard10(-/-) mice, suggesting that the enterohepatic cycling is impaired. STARD10 was also expressed in the gallbladder and small intestine where the expression level of apical sodium dependent bile acid transporter (ASBT) turned out to be markedly lower in Stard10(-/-) mice than in WT mice when measured under fed condition. Consistent with the above results, the fecal excretion of bile acids was significantly increased in Star...Continue Reading

Mentioned in this Paper

Bile acid transporter
Sterol 12-alpha-Hydroxylase
PPARA wt Allele
Bile Acid Measurement
Protein Family
Peroxisome Proliferator-Activated Receptors
Small Intestinal Wall Tissue
Liver Carcinoma
Candidate Disease Gene
Gallbladder (Mmhcc)

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