Disruption of the blood-brain barrier in collagen-induced arthritic mice

Neuroscience Letters
Tsuyoshi NishiokuYasufumi Kataoka

Abstract

Patients with rheumatoid arthritis (RA) are at higher risk of developing pathological cardiovascular and cerebrovascular events than non-RA subjects. Vascular endothelial dysfunction is involved in the induction of cardiovascular events and this process is also observed in patients with RA. Endothelial dysfunction impairs the integrity of the blood-brain barrier (BBB); this phenomenon also underlies brain damage in cerebrovascular diseases. This study was aimed at evaluating the influence of a chronic inflammatory state on BBB integrity in RA using collagen-induced arthritis (CIA), an animal model of RA. CIA was induced by intradermal injection of type II collagen emulsified with Freund's complete adjuvant at the base of the tail of DBA/1 mice. Cerebrovascular permeability was assessed by measurement of sodium fluorescein (Na-F) content in the brains of CIA mice. The expression level of tight junction proteins was investigated by immunoblotting and immunofluorescence of occludin and zonula occludens-1 (ZO-1). Cerebrovascular permeability to Na-F in the brain was increased in CIA mice. This CIA-induced BBB hyperpermeability was more remarkable in the advanced stage than that in the persistent stage of the arthritis. The expressi...Continue Reading

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Citations

Jun 28, 2012·Journal of Biomedical Science·Pi-Hung LiaoLi-Kuang Chen
Mar 31, 2012·Expert Opinion on Drug Metabolism & Toxicology·Travis T WagerPatrick Trapa
Sep 19, 2015·Journal of Pharmacological Sciences·Fuyuko TakataYasufumi Kataoka
Apr 19, 2016·Pain Management·Duygu B BasCamilla I Svensson
Oct 24, 2014·Frontiers in Cellular Neuroscience·Marcos F DosSantosVivaldo Moura-Neto
Jul 7, 2017·Science Translational Medicine·Fumitaka ShimizuJeffrey L Bennett
Feb 1, 2020·Current Medical Imaging Reviews·Sevil TokdemirAlpay Alkan
Jun 29, 2017·Clinical Rheumatology·Talita Siara Almeida BaptistaMoisés Evandro Bauer
Mar 13, 2021·Open Access Rheumatology : Research and Reviews·Anthony Sebba
Oct 2, 2021·Cellular & Molecular Immunology·Ian Galea
Apr 28, 2011·Current Opinion in Supportive and Palliative Care

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