PMID: 9189272Jun 1, 1997Paper

Disruption of the dopamine beta-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory

Behavioral Neuroscience
Steven A Thomas, Richard D Palmiter

Abstract

Mice unable to synthesize norepinephrine (NE) were created by targeted disruption of the dopamine beta-hydroxylase (DBH) gene. DBH-deficient (DBH -/-) mice display normal home cage activity; however, they swim more slowly than their littermates, and some drown. The mutant mice also perform less well on a rapidly rotating rod, and approximately 20% do not learn to walk when the rod begins to turn. Restoration of NE with dihydroxyphenylserine eliminated these motor deficits. DBH -/- mice exhibit normal learning and retention of a passive avoidance paradigm; however, they do not master an active-avoidance paradigm as readily as controls and exhibit more rapid extinction of the active-avoidance task. DBH -/- mice learn to find the hidden platform in the Morris water maze in spite of their slower swim speed and show normal preference for the correct quadrant in the transfer test immediately after training. However, this preference declines relative to controls during the next 2 days.

Citations

Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·R G Hill
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Luc JasminPeter T Ohara
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·John F CryanIrwin Lucki
May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cary L ScheidererLori L McMahon
May 27, 2010·Journal of the Association for Research in Otolaryngology : JARO·Stéphane F MaisonM Charles Liberman
Apr 8, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marieke JepmaSander Nieuwenhuis
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Keith SchutskySteven A Thomas
Feb 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming OuyangSteven A Thomas
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lei ZhangSteven A Thomas
Mar 13, 1999·Annual Review of Psychology·D Wahlsten

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