Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasis.

Proceedings of the National Academy of Sciences of the United States of America
Thorsten BergerTak W Mak

Abstract

Based largely on studies in xenograft models, lipocalin-2 (Lcn2) has been implicated in the progression of multiple types of human tumors, including breast cancer. Here we examine the role of Lcn2 in mammary tumorigenesis and lung metastasis using an in vivo molecular genetics approach. We crossed a well-characterized transgenic mouse model of breast cancer, the MMTV-PyMT (mouse mammary tumor virus-polyoma middle T antigen) mouse, with two independent gene-targeted Lcn2(-/-) mouse strains of the 129/Ola or C57BL/6 genetic background. The onset and progression of mammary tumor development and lung metastasis in the female progeny of these crosses were monitored over a 20-week period. Female Lcn2(-/-)MMTV-PyMT mice of the 129/Ola background (Lcn2(-/-)PyMT(129)) showed delayed onset of mammary tumors, and both Lcn2(-/-)PyMT(129) mice and Lcn2(-/-)MMTV-PyMT mice of the C57BL/6 background (Lcn2(-/-)PyMT(B6)) exhibited significant decreases in multiplicity and tumor burden (approximately 2- to 3-fold), as measured by total tumor weight and volume. At the molecular level, mammary tumors derived from Lcn2(-/-)PyMT(B6) females showed reduced matrix metalloproteinase-9 (MMP-9) activity and a lack of high molecular weight MMP activity. Ho...Continue Reading

References

Jan 1, 1989·Cancer Chemotherapy and Pharmacology·M M Tomayko, C P Reynolds
Mar 21, 1998·Genes & Development·L Hennighausen, G W Robinson
Dec 8, 1998·International Journal of Cancer. Journal International Du Cancer·S P StoeszM N Gould
Mar 14, 2000·Oncogene·D L Dankort, W J Muller
Nov 4, 2000·Biochimica Et Biophysica Acta·B AkerstromJ P Salier
Nov 4, 2000·Biochimica Et Biophysica Acta·D R FlowerC E Sansom
Dec 26, 2001·Oncogene·N Ichaso, S M Dilworth
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Aug 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cecilia A FernándezMarsha A Moses
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Thorsten BergerTak W Mak
Aug 5, 2006·Breast Cancer Research : BCR·Anna Fantozzi, Gerhard Christofori
Jun 8, 2007·Breast Cancer Research and Treatment·Maret BauerAndreas Friedl
Jul 3, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Frank J G M KubbenHein W Verspaget
Dec 17, 2008·Journal of Experimental & Clinical Cancer Research : CR·Han ShiWengong Yu
Feb 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jiang YangMarsha A Moses
Nov 6, 2009·Cancer Research·Xiaohong LengRalph B Arlinghaus

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Citations

Apr 19, 2013·Nature Reviews. Cancer·Suzy V Torti, Frank M Torti
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Fangfang BiHongxia Zhou
Sep 18, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiang YangMarsha A Moses
Mar 3, 2011·Cancer Research·Suzy V Torti, Frank M Torti
May 31, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yan SunWei Zhang
Jul 25, 2013·Critical Reviews in Oncogenesis·Suzy V Torti, Frank M Torti
Dec 24, 2011·Molecular and Cellular Endocrinology·Alison E Obr, Dean P Edwards
Nov 15, 2011·Cancer Letters·Jeffrey J RodvoldMaurizio Zanetti
Feb 26, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·B CabiaA B Crujeiras
May 23, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yun-Peng WangDae-Ghon Kim
Sep 22, 2010·Journal of Cellular Physiology·Xiaohong LengRalph B Arlinghaus
Feb 5, 2013·Biochimica Et Biophysica Acta·Erawan Borkham-KamphorstRalf Weiskirchen
Apr 3, 2016·The Journal of Pathology·Bilge ÖrenMichaela Jung
Jun 22, 2017·Biochemical and Biophysical Research Communications·Toshiro HaraTakeharu Sakamoto
Feb 6, 2018·Oncoimmunology·Christina MertensMichaela Jung
Nov 28, 2019·British Journal of Cancer·Claudia RehwaldMichaela Jung
Oct 6, 2017·Frontiers in Immunology·Michaela JungBernhard Brüne
Oct 21, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Navin R Mahadevan, Maurizio Zanetti
Jun 20, 2017·Annual Review of Nutrition·Xia XiaoMatam Vijay-Kumar
Jan 16, 2019·International Journal of Molecular Sciences·Michaela JungBernhard Brüne
Apr 20, 2014·Oncotarget·Saverio CandidoMassimo Libra
Sep 16, 2020·Cancer Research·Suzy V Torti, Frank M Torti

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