To understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes. We investigated 24 genes with variants associated with SD by GWAS; and 82 loci with putative subordinate roles with respect to SD-associated genes. We observed high ancestry-related frequency differences in common functional alleles in GWAS relevant genes and their interactive partners. Common functional alleles with high frequency differences demonstrated significant effects on the GWAS outcomes. Population differences in SD GWAS outcomes seem not to be influenced by general variation across the genome, but by ancestry-related local haplotype structures at SD-associated loci.
African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping
Large allele frequency differences between human continental groups are more likely to have occurred by drift during range expansions than by selection
Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence
The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach
VARIANT: Command Line, Web service and Web interface for fast and accurate functional characterization of variants found by Next-Generation Sequencing
Human genetic variation of CYP450 superfamily: analysis of functional diversity in worldwide populations
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication
Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene
Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci
Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample
Low frequency variants, collapsed based on biological knowledge, uncover complexity of population stratification in 1000 genomes project data
Human pharmacogenomic variation of antihypertensive drugs: from population genetics to personalized medicine
Gene-based sequencing identifies lipid-influencing variants with ethnicity-specific effects in African Americans
Racially classified social group differences in cigarette smoking, nicotine dependence, and readiness to quit
Geographic population structure analysis of worldwide human populations infers their biogeographical origins
Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans
Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1
A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus
Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors
Genetic variability in the humoral immune response to bovine herpesvirus-1 infection in dairy cattle and genetic correlations with performance traits
Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations.
Population diversity of the genetically determined TTR expression in human tissues and its implications in TTR amyloidosis
Cross-ancestry genome-wide association studies identified heterogeneous loci associated with differences of allele frequency and regulome tagging between participants of European descent and other ancestry groups from the UK Biobank.
Alcohol Use Disorder
Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.