Dissecting Arabidopsis Gβ signal transduction on the protein surface.

Plant Physiology
Kun JiangAlan M Jones

Abstract

The heterotrimeric G-protein complex provides signal amplification and target specificity. The Arabidopsis (Arabidopsis thaliana) Gβ-subunit of this complex (AGB1) interacts with and modulates the activity of target cytoplasmic proteins. This specificity resides in the structure of the interface between AGB1 and its targets. Important surface residues of AGB1, which were deduced from a comparative evolutionary approach, were mutated to dissect AGB1-dependent physiological functions. Analysis of the capacity of these mutants to complement well-established phenotypes of Gβ-null mutants revealed AGB1 residues critical for specific AGB1-mediated biological processes, including growth architecture, pathogen resistance, stomata-mediated leaf-air gas exchange, and possibly photosynthesis. These findings provide promising new avenues to direct the finely tuned engineering of crop yield and traits.

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Citations

Feb 28, 2013·Molecular Plant-microbe Interactions : MPMI·Miguel Angel TorresJeffery L Dangl
Mar 29, 2013·Open Biology·Daisuke UranoAlan M Jones
Jun 3, 2014·BMC Plant Biology·Alejandro C ColaneriAlan M Jones
Dec 10, 2013·Annual Review of Plant Biology·Daisuke Urano, Alan M Jones
Oct 6, 2014·Current Opinion in Plant Biology·Alejandro C Colaneri, Alan M Jones
Nov 12, 2015·International Journal of Molecular Sciences·Camilla J KørnerKarolina M Pajerowska-Mukhtar
Aug 28, 2014·Frontiers in Plant Science·Eva MiedesAntonio Molina
Sep 12, 2017·Frontiers in Plant Science·Meral Tunc-OzdemirMatthew P Torres
Aug 20, 2017·Scientific Reports·Guo-Liang YuanWei-Cai Yang

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