Dissecting Cell Lineages: From Microscope to Kaleidoscope

Cell
Unmesh Jadhav, Ramesh A Shivdasani

Abstract

Single-cell transcriptomics coupled with dynamic two-color fluorescence are used by Gehart et al. (2019) to elucidate adult mammalian cell trajectories in real time. The authors' close examination of intestinal enteroendocrine differentiation reveals new lineage features and shifting cell identities, and experiments in organoids uncover specific roles for transcriptional regulators identified by this approach.

Citations

Sep 21, 2020·Journal of Endodontics·Anthony J Smith
Aug 26, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Claudia CapdevilaKelley S Yan

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