Dissecting Endoplasmic Reticulum Unfolded Protein Response (UPRER ) in Managing Clandestine Modus Operandi of Alzheimer's Disease

Frontiers in Aging Neuroscience
Safikur RahmanRinki Minakshi

Abstract

Alzheimer's disease (AD), a neurodegenerative disorder, is most common cause of dementia witnessed among aged people. The pathophysiology of AD develops as a consequence of neurofibrillary tangle formation which consists of hyperphosphorylated microtubule associated tau protein and senile plaques of amyloid-β (Aβ) peptide in specific brain regions that result in synaptic loss and neuronal death. The feeble buffering capacity of endoplasmic reticulum (ER) proteostasis in AD is evident through alteration in unfolded protein response (UPR), where UPR markers express invariably in AD patient's brain samples. Aging weakens UPRER causing neuropathology and memory loss in AD. This review highlights molecular signatures of UPRER and its key molecular alliance that are affected in aging leading to the development of intriguing neuropathologies in AD. We present a summary of recent studies reporting usage of small molecules as inhibitors or activators of UPRER sensors/effectors in AD that showcase avenues for therapeutic interventions.

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Citations

Jan 16, 2020·International Journal of Molecular Sciences·Hiroshi KokubunTomohiko Aoe
Mar 25, 2020·International Journal of Molecular Sciences·Wioletta Rozpędek-KamińskaIreneusz Majsterek
Feb 9, 2019·Frontiers in Physiology·Meesha SharmaLaishram Rajendrakumar Singh
Oct 29, 2020·Reproductive Biomedicine Online·Tugba Ekiz-YilmazElif Guzel
Mar 12, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Sakthi Jothi Muthu, Prakash Seppan
Nov 12, 2018·Biochemical Pharmacology·Virginia CorreaniMaria d'Erme
May 18, 2021·Frontiers in Aging Neuroscience·Xue-Chun LiuGui-Hai Chen
Aug 29, 2021·Pharmaceutics·Mudasir Ahmad BhatArif Tasleem Jan

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Methods Mentioned

BETA
protein folding
transgenic
transgenics

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