PMID: 9543673Apr 17, 1998Paper

Dissecting leiomyoma of the uterus with extrauterine extension

Histopathology
M Fukunaga, S Ushigome

Abstract

Familiarity with benign uterine smooth muscle tumours with unusual growth patterns by gynaecologists and pathologists is essential in avoiding misdiagnosis and overtreatment. An enlarged uterus in a 35-year-old woman contained numerous, ill-defined nodules with marked hydropic changes which showed an extrauterine extension. Histologically, although some nodules had an appearance of conventional leiomyoma, the predominant part of the lesion was characterized by ill-defined spindle cell nodules with marked hydropic changes and irregular dissection of the myometrium. The cellularity was variable from area to area and there were neither nuclear atypia nor mitotic figures. No coagulative tumour necrosis was observed. The extrauterine components, which were in continuity with the intrauterine nodule, were histologically identical to the intrauterine nodules except for the complication of endometriosis. Immunohistochemically, the tumour cells were positive for vimentin, desmin, alpha-smooth muscle actin and muscle actin (HHF35). The tumour was DNA diploid by flow cytometry. The patient was well and without disease 6 months after hysterectomy. This tumour illustrates that rare benign smooth muscle tumours can proliferate in dissecting ...Continue Reading

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Citations

Feb 19, 2011·International Journal of Clinical Oncology·Kazim GezginçLema Tavli
Oct 31, 2001·Histopathology·N Wilkinson, T P Rollason
Jan 19, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·P B Clement
Jul 25, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·L M Roth, R J Reed
Feb 3, 2007·Obstetrics and Gynecology·M MathewS Shabnam
Apr 23, 2013·Asian Journal of Endoscopic Surgery·Hirohiko TanakaKenji Nagao
Apr 21, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Masaharu FukunagaNobuyuki Hiruta
Nov 24, 2006·Virchows Archiv : an International Journal of Pathology·Ksenya V ShelekhovaMichal Michal
Aug 6, 2016·Diagnostic Pathology·Ai ShimizuAkira Suzuki
Jun 20, 2012·International Journal of Surgical Pathology·Catherine C SmithOluwole Fadare
Feb 5, 2002·Archives of Pathology & Laboratory Medicine·W CheukJohn Y S Liu
Jul 10, 2004·Journal de radiologie·P Karila-CohenS Merran

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