Dissecting "PI3Kness": the complexity of personalized therapy for ovarian cancer.

Cancer Discovery
Robert C Bast, Gordon B Mills

Abstract

Epithelial ovarian cancers exhibit marked heterogeneity and can be divided into low-grade type I and more prevalent high-grade type II lesions that differ in stage at diagnosis, rate of growth, and susceptibility to platinum-based chemotherapy. Activation of the phosphatidylinositol 3' kinase (PI3K) pathway occurs in a significant fraction of both types of ovarian cancer, driven predominantly by mutations in type I and amplification in type II. Available cell lines do not often reflect the genotype of type II ovarian cancers, but studies with cell lines driven by mutation suggest that blocking activated AKT is necessary, but not sufficient to inhibit cancer cell growth. Inhibition of multiple signaling pathways will likely be required to achieve effective personalized therapy for patients whose cancers exhibit "PI3Kness."

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Citations

Jul 11, 2013·Nature Communications·Silvia DomckeNikolaus Schultz
Feb 13, 2013·Nature Reviews. Clinical Oncology·Jordi RodonJosep Tabernero
Jan 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Gavin P DunnWilliam C Hahn
Mar 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Kalpana KannanLaising Yen
Apr 18, 2013·International Journal of Molecular Sciences·Zachary C Dobbin, Charles N Landen
Feb 20, 2013·Cancer Growth and Metastasis·Stacy L WempeCarlos M Telleria
Apr 2, 2013·Cancer Growth and Metastasis·Carlos M Telleria
Jul 26, 2014·Genes & Cancer·Xiaobing DengEileen Friedman
May 5, 2017·Expert Review of Molecular Diagnostics·Wei-Lei YangRobert C Bast
Jun 22, 2017·The Journal of Biological Chemistry·Angela M GocherArthur M Edelman
Aug 16, 2018·Journal of Cancer Research and Clinical Oncology·Maria Luisa GasparriElisabetta Ferretti
Dec 20, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sarah P BlagdenHani Gabra

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