Dissecting spinal cord regeneration

Nature
Michael V Sofroniew

Abstract

The inability to recover functions lost after severe spinal cord injury has been recognized for millennia and was first attributed to a failure of spinal cord neural regeneration over 100 years ago. The last forty years have seen intense research into achieving such regeneration, but in spite of conceptual advances and many reports announcing successful interventions, progress has been slow and often controversial. Here, I examine consequential advances and setbacks, and critically consider assumptions underlying certain approaches. I argue that expanding mechanistic knowledge about multiple forms of neural regeneration, why they fail and how they can restore function will resolve conceptual contentions and push the field forward.

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R B Campenot
May 1, 1975·Developmental Biology·P C Letourneau
Jun 1, 1969·Brain Research·G Raisman
Mar 20, 1980·Nature·P M RichardsonA J Aguayo
Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Jun 6, 2000·Neuron·F M InglisR G Kalb
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·N WeidnerM H Tuszynski
Apr 12, 2002·Nature·Elizabeth J BradburyStephen B McMahon
Nov 9, 2002·Science·Tommaso PizzorussoLamberto Maffei
Apr 30, 2003·Neuron·Binhai ZhengMarc Tessier-Lavigne
Dec 1, 1954·The Journal of Comparative Neurology·C D CLEMENTE, W F WINDLE
Oct 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·R W SPERRY
Mar 1, 1964·Journal of Neurosurgery·R H WILKINS
Jan 22, 2004·Nature Reviews. Neuroscience·Jerry Silver, Jared H Miller
Feb 18, 2004·Nature Neuroscience·Florence M BareyreMartin E Schwab
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John H MartinZhuo Meng
Mar 17, 2004·Current Opinion in Neurobiology·Martin E Schwab
Apr 30, 2004·Journal of Neurotrauma·Michael D NorenbergAlex Marcillo
Jul 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Veronica J TomJerry Silver
Jan 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Binhai ZhengMarc Tessier-Lavigne
Apr 29, 2006·Journal of Biology·Jeannette E DaviesStephen J A Davies
Oct 4, 2006·Experimental Neurology·Paul LuMark H Tuszynski
Sep 29, 2007·BMC Neuroscience·Mohammed K Hossain-IbrahimPatrick N Anderson
Aug 4, 2009·Nature Neuroscience·Laura Taylor AltoMark H Tuszynski
Aug 12, 2009·Nature Neuroscience·Guillermo García-AlíasJames W Fawcett
Sep 22, 2009·Nature Neuroscience·Grégoire CourtineV Reggie Edgerton
Oct 1, 1947·The Journal of Comparative Neurology·J O BROWN, G P McCOUCH
Jul 2, 2010·Cold Spring Harbor Perspectives in Biology·Jonathan Raper, Carol Mason
Aug 13, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jae K LeeBinhai Zheng
Nov 16, 2010·Nature Neuroscience·Ephron S RosenzweigMark H Tuszynski
Jun 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Difei WangJames W Fawcett

❮ Previous
Next ❯

Citations

May 31, 2019·Journal of Medical Primatology·Jia-Sheng RaoXiao-Guang Li
Dec 4, 2019·The Journal of Clinical Investigation·Wenjing SunAndrea Tedeschi
Oct 28, 2019·Current Stem Cell Research & Therapy·Mehdi ForouzeshSeyed Esmaeil Khoshnam
Feb 23, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Maria Byrne
Nov 16, 2019·Nature Reviews. Neurology·Thomas H Hutson, Simone Di Giovanni
Feb 6, 2020·The Review of Scientific Instruments·Christian LiemersdorfJens Hauslage
Aug 21, 2019·Glia·Carole EscartinMaria-Angeles Carrillo-de Sauvage
Dec 4, 2019·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Rieko Muramatsu
Jun 13, 2020·Frontiers in Cellular Neuroscience·Mohammad-Masoud ZavvarianMichael G Fehlings
Jun 11, 2020·Nature Reviews. Neuroscience·Itzhak FischerMichael A Lane
Aug 30, 2019·Nature Communications·Elizabeth J Bradbury, Emily R Burnside
Aug 8, 2020·JCI Insight·Can Gollmann-TepeköylüJohannes Holfeld
Jun 5, 2019·Nature Medicine·Grégoire Courtine, Michael V Sofroniew
May 14, 2020·F1000Research·Mohammad-Masoud ZavvarianMichael Fehlings
Sep 26, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tuo YangGang Chen
Dec 10, 2020·Journal of Neurotrauma·Lin-Yu JinHai-Ying Liu
Dec 23, 2020·Open Biology·Sonia S Elder, Elaine Emmerson
Dec 11, 2020·Life Sciences·Yingli JingYan Yu
Jan 1, 2021·Frontiers in Cell and Developmental Biology·Inês Lago-BaldaiaSarah D Ackerman
Jan 27, 2021·Journal of Cellular and Molecular Medicine·Jiaqi BiYouxi Lin
Dec 12, 2019·ACS Chemical Neuroscience·Anusha DravidDarren Svirskis
Dec 24, 2020·Journal of Neurotrauma·Leslie R MorseUNKNOWN SCI 2020 Working Group
Feb 21, 2021·Developmental Cell·Dana Klatt ShawMayssa H Mokalled
Dec 15, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Simonetta PapaPietro Veglianese
Mar 2, 2021·Neural Regeneration Research·Wen-Zhao WangXiao-Ling Hou
Mar 2, 2019·Seminars in Cell & Developmental Biology·Yang D Teng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Related Papers

The Journal of Thoracic and Cardiovascular Surgery
Michael J Reardon, Alan B Lumsden
Journal of General Internal Medicine
M O'KeefeC Mulrow
© 2022 Meta ULC. All rights reserved