PMID: 9447936Feb 3, 1998Paper

Dissecting the frog inner ear with Gaussian noise. I. Application of high-order Wiener-kernel analysis

Hearing Research
P van DijkJ M Segenhout

Abstract

Wiener kernel analysis was used to characterize the auditory pathway from tympanic membrane to single primary auditory nerve fibers in the European edible frog, Rana esculenta. Nerve fiber signals were recorded in response to white Gaussian noise. By cross-correlating the noise stimulus and the nerve fiber response, we computed (1) the full second-order Wiener kernel, and (2) the diagonals of the zeroth- to fourth-order Wiener kernels. These diagonals are usually referred to as polynomial correlation functions. The measured Wiener kernels were fitted with a 'sandwich' model. A new fitting procedure was used to compute the response characteristics of (1) the first filter, (2) the static nonlinearity, and (3) the second filter, which form the functional components of the model. The first filter is a bandpass filter. In the majority of low frequency fibers, with best excitatory frequency (BEF) < 800 Hz, this filter was tuned to two frequencies. This dual tuning mechanism gives rise to 'off-diagonal' components in the second-order Wiener kernel. The static nonlinearity resembles a rectifier, and is dominated by second-order (quadratic) nonlinearity. As a function of BEF, the shape of the nonlinearity changes systematically. Finally...Continue Reading

References

Jan 1, 1978·The Journal of the Acoustical Society of America·E de Boer, H R de Jongh
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Dec 1, 1990·The Journal of the Acoustical Society of America·J W HorstG R Farley
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Citations

Mar 1, 2005·Journal of the Association for Research in Otolaryngology : JARO·Sebastiaan W F MeenderinkPim van Dijk
Feb 27, 2001·Hearing Research·P van Dijk, G A Manley
Sep 3, 2002·Hearing Research·Edwin R LewisWalter M Yamada
Nov 16, 2002·Hearing Research·Edwin R LewisWalter M Yamada
Jan 22, 2005·PLoS Biology·Tim Gollisch, Andreas M V Herz
Aug 27, 2005·The Journal of the Acoustical Society of America·Sebastiaan W F Meenderink, Pim van Dijk
May 26, 2006·Journal of the Association for Research in Otolaryngology : JARO·Sebastiaan W F Meenderink, Pim van Dijk
Jun 3, 2009·Journal of the Association for Research in Otolaryngology : JARO·R L M SchoffelenP van Dijk
Feb 13, 2010·Hearing Research·Pim Van DijkSebastiaan W F Meenderink
Mar 3, 2007·Hearing Research·Michael G Sneary, Edwin R Lewis
Dec 7, 2000·The Journal of the Acoustical Society of America·B MaatP van Dijk
Jun 17, 2005·The Journal of the Acoustical Society of America·Sebastiaan W F MeenderinkPeter M Narins
Jan 22, 2005·Journal of Neurophysiology·Alberto Recio-SpinosoMario A Ruggero
Jul 16, 2005·The Journal of the Acoustical Society of America·James M HarteHenry J Rice

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