Dissecting the Heterogeneity of Treatment Response in First-Episode Schizophrenia

Schizophrenia Bulletin
Anil K Malhotra

Abstract

The Mental Health Centers for Intervention Development and Applied Research (CIDAR) program prioritized research to provide an evidence base for biomarker development. At the Zucker Hillside Hospital (ZHH), our CIDAR grant supported research on a comprehensive investigation of treatment response and outcome in first episode schizophrenia. Results provide evidence that baseline neuroimaging, neurocognitive, and genetic measures are significantly associated with clinical response to treatment, and that our currently available interventions can effectively treat aspects of psychotic illness, as well as potentially reduce comorbidity associated with illness. Future research may include combining modalities to more robustly predict response and identify treatment targets, as well as to further develop more effective intervention strategies for these devastating and disabling disorders.

References

Jun 6, 2007·Archives of General Psychiatry·Richard S E KeefeUNKNOWN Neurocognitive Working Group
Mar 3, 2010·The American Journal of Psychiatry·Jian-Ping ZhangAnil K Malhotra
Jun 7, 2013·Circulation·UNKNOWN WRITING COMMITTEE MEMBERSUNKNOWN American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
Feb 20, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philip R SzeszkoAnil K Malhotra
May 7, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharon H GiordanoUNKNOWN American Society of Clinical Oncology
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium
Jan 9, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Miklos ArgyelanPhilip R Szeszko
Jan 9, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alan AnticevicQiyong Gong

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Citations

Sep 27, 2015·Schizophrenia Bulletin·Joey W TrampushAnil K Malhotra
Apr 11, 2019·JAMA Psychiatry·Dag AlnæsUNKNOWN Karolinska Schizophrenia Project Consortium
Apr 3, 2020·Nature Communications·Feng ZhuXiancang Ma
Aug 11, 2018·Frontiers in Psychiatry·Ruta SamanaiteAlice Egerton
Jul 31, 2021·Schizophrenia Research·Aniol Santo-AnglesJens Schwarzbach
Sep 12, 2021·Schizophrenia Bulletin·Yuan XiaoQiyong Gong

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