Dissecting the human serum antibody response to secondary dengue virus infections

PLoS Neglected Tropical Diseases
Bhumi PatelAravinda M de Silva

Abstract

Dengue viruses (DENVs) are mosquito-borne flaviviruses and the causative agents of dengue fever and dengue hemorrhagic fever. As there are four serotypes of DENV (DENV1-4), people can be infected multiple times, each time with a new serotype. Primary infections stimulate antibodies that mainly neutralize the serotype of infection (type-specific), whereas secondary infections stimulate responses that cross-neutralize 2 or more serotypes. Previous studies have demonstrated that neutralizing antibodies induced by primary infections recognize tertiary and quaternary structure epitopes on the viral envelope (E) protein that are unique to each serotype. The goal of the current study was to determine the properties of neutralizing antibodies induced after secondary infection with a different (heterotypic) DENV serotypes. We evaluated whether polyclonal neutralizing antibody responses after secondary infections consist of distinct populations of type-specific antibodies to each serotype encountered or a new population of broadly cross-neutralizing antibodies. We observed two types of responses: in some individuals exposed to secondary infections, DENV neutralization was dominated by cross-reactive antibodies, whereas in other individua...Continue Reading

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Citations

Jan 3, 2018·The Journal of Infectious Diseases·Adriana GoncalvesAnnelies Wilder-Smith
Feb 24, 2018·International Journal of Environmental Research and Public Health·Claude RothAnavaj Sakuntabhai
Sep 29, 2018·Annual Review of Virology·Kimberly A Dowd, Theodore C Pierson
Mar 7, 2020·Tropical Medicine and Infectious Disease·Kelli L BarrMaureen T Long
Apr 7, 2020·Journal of Biomolecular Structure & Dynamics·Vasudevan SaranyaSubramaniam Vijayakumar
Nov 30, 2019·Immunology·Alba GrifoniDaniela Weiskopf
Aug 29, 2019·Frontiers in Immunology·Audrey L ButlerGalit Alter
Feb 28, 2019·Nature Communications·Paulina AndradeEva Harris
Aug 29, 2020·Science·Leah C KatzelnickEva Harris
Jan 10, 2020·Cell Host & Microbe·Matthew G ZimmermanMehul S Suthar
Mar 30, 2018·Current Opinion in Virology·Leah C Katzelnick, Eva Harris

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Methods Mentioned

BETA
ELISA
ELISAs

Software Mentioned

GraphPad Prism

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