Dissecting the Molecular Mechanisms of the Tropism of Varicella-Zoster Virus for Human T Cells.

Journal of Virology
Nandini Sen, Ann M Arvin

Abstract

Studies of varicella-zoster virus (VZV) tropism for T cells support their role in viral transport to the skin during primary infection. Multiparametric single-cell mass cytometry demonstrates that, instead of preferentially infecting skin-homing T cells, VZV alters cell signaling and remodels surface proteins to enhance T cell skin trafficking. Viral proteins dispensable in skin, such as that encoded by open reading frame 66, are necessary in T cells. Interference with VZV T cell tropism may offer novel strategies for drug and vaccine design.

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Citations

Feb 8, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Badrul IslamBart C Jacobs
Sep 25, 2018·The Journal of Infectious Diseases·Michael Gershon, Anne Gershon
May 1, 2018·PLoS Pathogens·Tessa Mollie CampbellAllison Abendroth
Feb 11, 2020·Frontiers in Immunology·Chelsea GeradaAllison Abendroth
Oct 2, 2020·Current Clinical Microbiology Reports·Océane Sorel, Ilhem Messaoudi
May 11, 2016·Clinical and Experimental Immunology·N Arnold, I Messaoudi
Jan 9, 2019·Frontiers in Microbiology·Océane Sorel, Ilhem Messaoudi
Jul 17, 2020·Frontiers in Immunology·Richard B KennedyGregory A Poland

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