Dissecting the nutrigenomics, diabetes, and gastrointestinal disease interface: from risk assessment to health intervention

Omics : a Journal of Integrative Biology
Lynnette R Ferguson

Abstract

The promise of nutrigenomics is of personalized nutrition that will lead to optimization or maintenance of good health and/or prevention of the development of chronic diseases. Type 2 diabetes mellitus (T2DM) is a leading health problem throughout the world. Adherence to a Mediterranean-style diet, regulation of carbohydrate intake, and regular exercise may be desirable. Four key genes were originally identified: KCNJ11, potassium inwardly rectifying channel, subfamily J, member 11 gene; PPAR-gamma, peroxisome proliferator activated receptor-gamma; TCF2, transcription factor 2, hepatic; WFS1, Wolfram syndrome 1. However, genome-wide association studies are accelerating our knowledge of the genetics of complex diseases, and have identified seven other key genes in T2DM: CDKAL1, CDK5 regulatory subunit associated protein-like 1; CDKN2, cyclin-dependent kinase inhibitor 2A; FTO, fat mass and obesity associated; HHEX, haematopoietically expressed homeobox; IDE, insulin-degrading enzyme; IGF2BP2, insulin-like growth factor 2 mRNA-binding protein 2; SLC30A8, solute carrier family 30 (zinc transporter), member 8; TCF7L2, transcription factor 7-like 2 (T-cell specific, HMG-box). Gene-nutrient or gene-environment interactions may be imp...Continue Reading

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Citations

Dec 2, 2008·Omics : a Journal of Integrative Biology·Béatrice Godard, Vural Ozdemir
Jan 15, 2014·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Anahita ShaerMehrdad Shariati
Sep 20, 2011·Cellular Signalling·Erick Contreras-VallejosChristian Gonzalez-Billault
Nov 30, 2016·Journal of Diabetes Research·Hemant KulkarniJohn Blangero

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