Dissecting the Therapeutic Relevance of Gene Therapy in NeuroAIDS: An Evolving Epidemic.

Current Gene Therapy
Bushra NabiJaved Ali

Abstract

NeuroAIDS, a disease incorporating both infectious and neurodegenerative pathways, is still a formidable challenge for the researchers to deal with. The primary concern for the treatment of neuroAIDS still remains the inaccessibility of the viral reservoir, making it indispensable for novel techniques to be continuously innovated. Since the brain serves as a reservoir for viral replication, it is pragmatic and a prerequisite to overcome the related barriers in order to improve the drug delivery to the brain. The current treatment ideology is based on the combinatorial approach of a mocktail of antiretroviral drugs. However, complete eradication of the disease could not be achieved. Thereby the arena of gene-based cellular delivery is trending and has created a niche for itself in the present scenario. To establish the supremacy of gene delivery, it is advisable to have a better understanding of the molecular mechanism involved in the due process. The mechanism associated with the activity of the anti-HIV gene lies in their intrinsic property to impart resistance to the HIV infection by targeting the viral entry channels. This review principally emphasizes on different types of gene therapies explored so far for the management o...Continue Reading

References

Feb 18, 2017·Cellular and Molecular Life Sciences : CMLS·Kamel KhaliliJeffrey M Jacobson
Sep 29, 2019·Seminars in Cancer Biology·Faheem Hyder PottooMohammad Amjad Kamal
May 15, 2020·Microbiology and Molecular Biology Reviews : MMBR·Melinda JudgePeter Le Souëf

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Citations

Oct 16, 2020·Current Gene Therapy·Ghulam Md Ashraf, Md Sahab Uddin

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