Dissection of hepatic versus extra-hepatic insulin clearance: Ethnic differences in childhood

Diabetes, Obesity & Metabolism
Francesca PiccininiRichard N Bergman

Abstract

Adult African American (AA) women have one third of the hepatic insulin clearance of European American (EA) women. This lower hepatic (but not extra-hepatic) insulin clearance in AA individuals is associated with higher plasma insulin concentrations. This study aims to understand whether impairment of hepatic insulin clearance is seen in AA individuals since childhood, possibly suggesting that genetic/epigenetic factors, rather than lifestyle only, contribute to this. A total of 203 children (105 male and 98 female (55 AA, 88 EA and 60 Hispanic American [HA]; ages, 7-13 years; mean BMI, 19 kg/m2 )) underwent the frequently applied intravenous glucose tolerance test (FSIGT) at the University of Alabama at Birmingham, General Clinical Research Center and Department of Nutrition Sciences. Glucose, insulin and C-peptide levels were measured and hepatic and extra-hepatic insulin clearances were calculated using mathematical modelling. Fractional hepatic insulin extraction (FEL ) was lower in AA than in EA children (mean (SD), 19% (20%) vs 33% (20%); P = 0.0007). Adjusting for age, Tanner stage and body fat, FEL was lower in AA than in EA children (P = 0.0012), and there was a slight sex-related difference (FEL, 24% (10%) vs 29% (10%...Continue Reading

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Citations

Apr 18, 2020·Journal of Internal Medicine·J H Goedecke, T Olsson
Mar 20, 2020·The Journal of Clinical Investigation·Gordon I SmithSamuel Klein
Jun 4, 2020·Diabetes, Obesity & Metabolism·Meera LadwaLouise M Goff
Nov 30, 2019·Journal of Diabetes Research·M LadwaL M Goff
Dec 28, 2019·The American Journal of Clinical Nutrition·Jeannie TayBarbara A Gower
Jul 17, 2019·The Proceedings of the Nutrition Society·Louise M GoffOluwatoyosi Bello
Sep 11, 2020·Diabetes Care·Francesca Piccinini, Richard N Bergman
Feb 26, 2021·Metabolism: Clinical and Experimental·Diego O BorgesM Paula Macedo
Mar 5, 2021·Frontiers in Endocrinology·Richard N Bergman

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