PMID: 15240697Jul 9, 2004Paper

Dissection of the HLA-DR4 peptide repertoire in endocrine epithelial cells: strong influence of invariant chain and HLA-DM expression on the nature of ligands

The Journal of Immunology : Official Journal of the American Association of Immunologists
Aura MuntasellDolores Jaraquemada

Abstract

Class II MHC (MHC II) expression is restricted to professional APCs and thymic epithelium but it also occurs in the epithelial cells of autoimmune organs which are the unique targets of the CD4 autoreactive T cells in endocrine autoimmune diseases. This specificity is presumably conditioned by an epithelium-specific peptide repertoire associated to MHC II at the cell surface. MHC II expression and function is dependent on the action of two main chaperones, invariant chain (Ii) and DM, whose expression is coregulated with MHC II. However, there is limited information about the in vivo expression levels of these molecules and uncoordinated expression has been demonstrated in class II-positive epithelial cells that may influence the MHC-associated peptide repertoires and the outcome of the autoimmune response. We have examined the pool of peptides associated to DR4 molecules expressed by a neuroendocrine epithelial cell and the consequences of Ii and DM coexpression. The RINm5F rat insulinoma cell line was transfected with HLA-DRB1*0401, Ii, and DM molecules in four different combinations: RIN-DR4, -DR4Ii, -DR4DM, and -DR4IiDM. The analysis of the peptide repertoire and the identification of the DR4 naturally processed ligands in ...Continue Reading

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Citations

Feb 9, 2005·Annals of the New York Academy of Sciences·Silvia RathmannIvana Durinovic-Belló
Oct 26, 2005·Cell Death and Differentiation·D Schmid, C Münz
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laia MuixíDolores Jaraquemada
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