Dissection of the human antibody response to the malaria antigen Pf155/RESA into epitope specific components.

Immunological Reviews
H PerlmannA Björkman

Abstract

The development of vaccines is presently receiving major attention in malaria research. As it is not possible to base malaria vaccines on the use of killed or attenuated organisms, the vaccines which are being developed are subunit vaccines in which the immunogens consist of defined parasite antigens or antigenic fragments. Since protective immunity to malaria involves both antibody-dependent and antibody-independent mechanisms, the immunogens in a subunit vaccine must have the capacity to induce relevant B- and T-cell responses in the majority of vaccinees. In turn, this requires good knowledge of these responses in humans who have acquired immunity through natural infection. In this paper we have summarized our recent work on the dissection into epitope-specific components of the human antibody response to the Plasmodium falciparum antigen Pf155/RESA, a recognized candidate for a vaccine against the asexual blood stages of this parasite. Epitope mapping of the antigen by means of short synthetic peptides led to the identification in several molecular regions of short amino acid sequences constituting linear and probably immunodominant B-cell epitopes. The antigenically most active region was located in the C-terminus of the m...Continue Reading

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Citations

Jun 30, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H A GihaG Elghazali
Jan 3, 1994·Journal of Immunological Methods·A RoyV S Chauhan
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Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K SjöbergP Perlmann
May 9, 2006·Microbes and Infection·Jean Birame SarrFlorence Migot-Nabias

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