PMID: 8613699Apr 1, 1996Paper

Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice

Journal of Leukocyte Biology
L ProbertG Kollias

Abstract

With increasing awareness that seemingly diverse immune-mediated diseases involve similar pathogenetic mechanisms, and the identification of a growing number of key effector molecules, it is becoming possible to design and generate effective transgenic models for such diseases. Tumor necrosis factor (TNF) plays a prominent role in immune and host defense responses and there is strong evidence that abnormal TNF production contributes to disease initiation and progression in rheumatoid arthritis, systemic inflammatory response syndrome, diabetes, multiple sclerosis, and many other immune-mediated disorders. The generation of TNF transgenic mice, in which TNF production is deregulated, has provided us with direct evidence that, in vivo, this cytokine can indeed trigger the development of such complex disease phenotypes. Transgenic mice that have been engineered to overexpress human or murine TNF molecules in peripheral joints, T cells, or neurons of the central nervous system represent important animal models for human rheumatoid arthritis, systemic inflammation, and multiple sclerosis, respectively. In addition to establishing a central role for TNF in such diseases, these animal models have already proved valuable for identifyin...Continue Reading

Citations

Jul 22, 1999·European Journal of Haematology·H GlosliH Prydz
Jul 5, 2005·Expert Opinion on Investigational Drugs·F C Nelson, A Zask
Jul 25, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chidozie J AmuzieJames J Pestka
Dec 19, 2016·Nature Reviews. Immunology·Mingui Fu, Perry J Blackshear
Feb 27, 2014·The Journal of Clinical Investigation·Roanne KeetonMuazzam Jacobs
Sep 6, 2000·Nature Biotechnology·A W BledsoeC D Morrow
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuo NikiNorihiro Tada
Apr 4, 2017·International Immunology·Kazuhiko Maeda, Shizuo Akira
Jul 17, 2003·American Journal of Physiology. Renal Physiology·Ganesan Ramesh, W Brian Reeves
Nov 26, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kenneth A Voss
Oct 7, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chidozie J Amuzie, James J Pestka
Feb 28, 2014·Arthritis & Rheumatology·Harini RaghuMatthew J Flick
May 27, 2017·Journal of Leukocyte Biology·Marina S DrutskayaSergei A Nedospasov
Nov 2, 2018·International Journal of Molecular Sciences·Jeong-Min ParkTae-Hong Kang
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M KhalilB Diamond

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.