PMID: 6978927Jun 1, 1982Paper

Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses

The Journal of Experimental Medicine
H WagnerK Pfizenmaier

Abstract

Evidence is presented that interleukin 2 (IL-2) is not sufficient to cause the differentiation of primary cytotoxic T lymphocytes (CTL). Sources of IL-2 were compared for their ability to cause proliferation as well as differentiation into CTL. Whereas all factors caused proliferation, only the crude Con A supernatant had cytotoxic T cell differentiation factor (CTDF) activity. Furthermore, factors absorbed with an IL-2-dependent cell line to remove IL-2 still retained CTDF activity. Thus, IL-2 functions to cause clonal expansion of CTL precursors preactivated by antigen or mitogen, but for their differentiation into CTL, an additional factor is required, here called CTDF.

References

Nov 1, 1981·The Journal of Experimental Medicine·H J LeibsonJ W Kappler
Feb 14, 1980·Nature·E L LarssonA Coutinho
Nov 1, 1981·The Journal of Experimental Medicine·R J RobbK A Smith

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Citations

Oct 15, 1985·Cellular Immunology·J W HootonV Paetkau
Jul 1, 1983·Mechanisms of Ageing and Development·V K GhantaR N Hiramoto
Jun 1, 1983·Immunopharmacology·M M Zatz, A L Goldstein
May 1, 1984·Veterinary Immunology and Immunopathology·B T Rouse, D W Horohov
Jan 1, 1987·Immunology Today·E C Böttger, D Bitter-Suerman
Nov 16, 2006·Cancer Biotherapy & Radiopharmaceuticals·Patrizia PellegriniDomenico Adorno
Nov 16, 2006·Cancer Biotherapy & Radiopharmaceuticals·Anna Maria BerghellaDomenico Adorno
Sep 1, 1984·Kidney International·T B Strom
Jan 1, 1988·Annals of the New York Academy of Sciences·D Cassell, J Forman
Feb 1, 1985·Scandinavian Journal of Immunology·P J Converse, A D Hess
Apr 1, 1987·Scandinavian Journal of Immunology·G GromoF H Bach
Jul 4, 2013·Biochimica Et Biophysica Acta·Savita LochabArun Kumar Trivedi
Jan 1, 1984·Immunology Today·G G Klaus, C M Hawrylowicz
Apr 1, 1992·Biological Trace Element Research·L Kiremidjian-SchumacherG Stotzky
Nov 1, 1984·European Journal of Immunology·R DevosW Fiers
Jul 1, 1986·European Journal of Immunology·A Schäfer, W Schmidt
Aug 20, 1987·The New England Journal of Medicine·F H Bach, D H Sachs
Jul 1, 1986·European Journal of Immunology·L K ChenA Bensussan
Jun 1, 1989·European Journal of Immunology·E TinoisM Stanley

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