Dissection of Z-disc myopalladin gene network involved in the development of restrictive cardiomyopathy using system genetics approach

World Journal of Cardiology
Qingqing GuEnkhsaikhan Purevjav

Abstract

To investigate the regulation of Myopalladin (Mypn) and identify its gene network involved in restrictive cardiomyopathy (RCM). Gene expression values were measured in the heart of a large family of BXD recombinant inbred (RI) mice derived from C57BL/6J and DBA/2J. The proteomics data were collected from Mypn knock-in and knock-out mice. Expression quantitative trait locus (eQTL) mapping methods and gene enrichment analysis were used to identify Mypn regulation, gene pathway and co-expression networks. A wide range of variation was found in expression of Mypn among BXD strains. We identified upstream genetic loci at chromosome 1 and 5 that modulate the expression of Mypn. Candidate genes within these loci include Ncoa2, Vcpip1, Sgk3, and Lgi2. We also identified 15 sarcomeric genes interacting with Mypn and constructed the gene network. Two novel members of this network (Syne1 and Myom1) have been confirmed at the protein level. Several members in this network are already known to relate to cardiomyopathy with some novel genes candidates that could be involved in RCM. Using systematic genetics approach, we constructed Mypn co-expression networks that define the biological process categories within which similarly regulated gene...Continue Reading

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Citations

Jun 28, 2018·Molecular & Cellular Proteomics : MCP·Evan G WilliamsRuedi Aebersold
Feb 3, 2021·International Journal of Cardiology·Fuyi XuYao Sun
Apr 17, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Ramona M VejandlaEnkhsaikhan Purevjav
May 6, 2021·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Ting ZhaoYubi Lin

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Methods Mentioned

BETA
genotyping
electrophoresis

Software Mentioned

Cytoscape Cohesion Analysis Tool ( GCAT )
set Cohesion Analysis Tool
DeCyder
Chillibot
GeneNetwork
WebQTL
Gene
Mypn

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