Disseminate Recurrent Folliculitis and Hidradenitis Suppurativa Are Associated Conditions: Results From a Retrospective Study of 131 Patients With Down Syndrome and a Cohort of 12,351 Pediatric Controls

Dermatology Practical & Conceptual
Andrea SechiMarco A Chessa

Abstract

Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent skin disease of the pilosebaceous unit characterized by protean manifestations. Several studies have found an increased incidence and earlier presentation of this disease in patients carrying trisomy 21. Patients with Down syndrome (DS) have a higher risk of developing a wide range of cutaneous manifestations, including HS and chronic folliculitis. Recently, disseminate recurrent folliculitis (DRF) has been reported as an atypical monosymptomatic feature of HS at its onset. To assess the prevalence of HS and DRF by comparing a cohort of patients carrying trisomy 21 vs pediatric controls. A retrospective 2-year monocentric clinical study was performed by collecting clinical data of 131 patients with DS, aged 4-36 years, followed at the Dermatology Unit and Down Syndrome Regional Center of Bologna University. Data were matched with those coming from 12,351 pediatric controls. In DS patients, DRF and HS showed a prevalence of, respectively, 6.8% and 24.4%, while 5.3% of patients presented both diseases. In the control group the prevalence for HS+ and DRF+ was 0.5% and 1.2%, respectively, with a 0.14% of overlap cases. The association between HS and DRF proved to b...Continue Reading

Citations

Jun 11, 2020·Pediatric Dermatology·Jillian F RorkLeah Belazarian
Sep 7, 2020·Pediatric Dermatology·Megan LamRaed Alhusayen
Feb 19, 2021·International Journal of Dermatology·Monica ShahChristopher Sayed
Jul 18, 2021·Clinics in Dermatology·Simone GarcovichAngelo Valerio Marzano
Aug 22, 2021·Pediatric Dermatology·Chenin RyanJillian F Rork
Oct 12, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Elia RosiFrancesca Prignano

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