Disseminated cellulitic cryptococcosis in the setting of prednisone monotherapy for pemphigus vulgaris

The Journal of Dermatology
Simon S YooEric C Vonderheid

Abstract

Cryptococcal infections are seen mainly in immunocompromised hosts. The cutaneous manifestations of infection can include papules, plaques, nodules, vesicles, ulcers, ecchymosis, and, rarely, cellulitis. Cryptococcal meningitis is a life-threatening complication of this disease. Pemphigus vulgaris is a rare auto-immune blistering disease that can also be life-threatening. Treatment of pemphigus commonly entails both corticosteroids and steroid-sparing agents. We present a case of disseminated cryptococcal infection in a patient with pemphigus vulgaris treated with high dose corticosteroids as monotherapy. This case provides an opportunity to discuss the difficulty of managing two potentially mortal conditions in which the treatment of pemphigus vulgaris may exacerbate the disseminated cryptococcal infection.

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Citations

Aug 12, 2009·Clinical and Experimental Dermatology·M AdachiH Kobayashi
Jan 16, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Sandra Lopes Mattos e DinatoNey Romiti
Mar 10, 2006·Plastic and Reconstructive Surgery·Ali Al-AttarRichard J Redett
May 15, 2008·International Journal of Dermatology·Emily A MoosbruggerStephen M Kralovic

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