Disseminated cortical and subcortical lesions in neonatal enterovirus 71 encephalitis.

Journal of Neurovirology
Ryoko NakamuraRyutaro Kira

Abstract

Enteroviruses are one of the most important causes of viral encephalitis in the neonatal period. However, the non-specificity of the symptoms presented renders its diagnosis challenging. Intracranial MRI has been reported to be a very useful imaging modality that can detect the characteristic white matter lesions around the periventricular regions. In this study, we report a case of a patient with neonatal encephalitis who presented with normal white blood cell counts in the initial cerebrospinal fluid analysis. A lumbar puncture retap identified pleocytosis, and polymerase chain reaction assays detected enterovirus 71 in the blood and stool samples. Furthermore, MRI revealed atypical disseminated cortical and subcortical white matter lesions on diffusion weighted images, and neuroradiological re-evaluation showed necrotic changes 2 weeks later. This unique case expands our knowledge of the spectrum of neurological disorders due to enterovirus 71 infection in neonatal period.

References

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Sep 19, 2006·Brain & Development·Tetsuo KubotaKazuyoshi Watanabe
Oct 23, 2010·Lancet Neurology·Mong How OoiTom Solomon
Jul 19, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A VenkatesanUNKNOWN International Encephalitis Consortium
Feb 4, 2014·The Lancet Infectious Diseases·Weijia XingHongjie Yu
Jun 10, 2014·Journal of Paediatrics and Child Health·Tai WuTian-Ming Yuan
Feb 6, 2020·BMC Public Health·Maria Melissa Ann JiaoAmado Tandoc

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