Disseminated cryptococcal infection with eosinophilia in a healthy person

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Hiromichi YamaguchiToshihito Shinagawa

Abstract

A 23-year-old man with no recent medical history was hospitalized complaining of high fever and cough. In addition to very marked eosinophilia, chest X-ray revealed extensive bronchovascular bundle thickening. Transbronchial lung biopsy (TBLB) showed moderate eosinophil infiltration. Cryptococcus neoformans infection was diagnosed, based on blood culture, cerebrospinal fluid culture, urine culture, and lung biopsy specimens. The eosinophilia was successfully alleviated by treatment for cryptococcal meningitis. Furthermore, cryptococcal sepsis resolved with amphotericin B and 5-flucytosine treatment. Eosinophilia commonly occurs following chronic Aspergillus infection, but the present case suggests the involvement of Cryptococcus in another mechanism for eosinophilia.

References

Jan 1, 1978·International Archives of Allergy and Applied Immunology·R G SlavinP Winzenburger
Oct 1, 1987·Chest·L Wasser, W Talavera
Jul 1, 1974·The Journal of Infectious Diseases·W R SalyerR D Baker
May 1, 1984·AJR. American Journal of Roentgenology·M B KhouryC E Putman
Aug 1, 1995·Southern Medical Journal·J C StarrJ Montgomery
Dec 1, 1995·The Pediatric Infectious Disease Journal·R K MarwahaR K Vasishta
Aug 1, 1995·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·B Z GartyM Nitzan
Apr 22, 2004·Internal Medicine·Hiroshi OhnishiJitsuo Higaki

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Citations

Nov 26, 2015·Future Microbiology·Alison J EastmanMichal A Olszewski
Dec 3, 2010·Journal of Chemotherapy·M BassettiC Viscoli
Dec 17, 2014·Fungal Genetics and Biology : FG & B·Josie F Gibson, Simon A Johnston
Apr 14, 2015·Future Microbiology·Soma Rohatgi, Liise-Anne Pirofski
Apr 14, 2016·Infection and Immunity·Lena J Heung, Tobias M Hohl
Feb 28, 2016·The Journal of Microbiology·Camaron Hole, Floyd L Wormley
Oct 13, 2017·Internal Medicine·Tetsuya YokoyamaTomoaki Iwanaga
Sep 25, 2017·Journal of Fungi·Lena J Heung
Oct 22, 2010·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Naoki KishidaNorio Ohmagari
Apr 30, 2017·BMC Pulmonary Medicine·Taizou HiranoMasakazu Ichinose
Apr 2, 2021·BMJ Case Reports·Syed Muhammad ZubairAli Bin Sarwar Zubairi
Jan 19, 2012·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Yuko KomaseChiharu Kawakami

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