Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia in a HIV-negative patient with cirrhosis: a case report.

Cases Journal
Baligh Ramzi YehiaDavid N Hager

Abstract

Cryptococcus neoformans is an encapsulated yeast that causes serious infections in immunocompromised populations. The majority of cases occur in HIV-infected individuals. Disseminated disease is uncommon, and very rarely includes peritonitis. We report a case of a 41-year-old, HIV-negative, Caucasian man with alcoholic liver cirrhosis who presented with fever and seizure. Disseminated cryptococcosis with meningitis, peritonitis, and cryptococcemia was diagnosed, and despite adequate treatment the patient developed multi-system organ failure and eventually expired. Disseminated cryptococcosis, particularly with peritonitis, is an uncommon manifestation of Cryptococcus neoformans infection. Liver cirrhosis serves as a risk factor for disseminated disease in HIV-negative patients. A high clinical suspicion and early initiation of therapy is needed to recognize and treat patients effectively.

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Citations

Mar 16, 2012·Internal and Emergency Medicine·Diana SpinelliMaria Domenica Cappellini
Sep 7, 2012·Case Reports in Pathology·S SuchithaG V Manjunath
Aug 20, 2014·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Chinmaya Kumar BalShiv Kumar Sarin
Apr 14, 2011·Diagnostic Cytopathology·Puja SinghNitin Gangane
Jul 21, 2011·Asian Pacific Journal of Tropical Medicine·Rupashree SundarRau Neeleshwar Radhakrishna
Feb 7, 2015·Indian Journal of Medical Microbiology·H KaurS M Rudramurthy
Mar 2, 2018·Journal of Fungi·Patricia EscandónElizabeth Castañeda
Jul 20, 2017·BMJ Case Reports·Pradeep MadaAndrew Stevenson Joel Chandranesan
May 14, 2018·BMJ Case Reports·Ali Hassoun, Neha Mehrotra
Dec 18, 2016·Journal of Community Hospital Internal Medicine Perspectives·Manasa KandulaMeenakshy K Aiyer
Mar 24, 2018·Indian Journal of Pathology & Microbiology·Supreet Kumar MohantyDipendra Kumar Mitra
Jul 13, 2013·Mycopathologia·Rosianne Assis de Sousa TsujisakiMarilene Rodrigues Chang
Apr 22, 2020·Proceedings·Amy E Barnett, Karen B Brust
Jul 9, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Qi-Hui ZhouZhi Chen
Nov 23, 2021·International Journal of Surgical Pathology·Velaphi Glenda Makhubela, Moshawa Calvin Khaba

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Methods Mentioned

BETA
gastric bypass

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