Abstract
The clinical and pathological features are described in a child with ataxia-telangiectasia, complicated by fatal disseminated herpes simplex virus infection. Herpes simplex virus was isolated from the patient's blood, and the histopathological findings in the skin, liver and adrenals were consistent with herpes simplex virus infection. The patient had a combined immune deficiency state, as a part of the ataxia-telangiectasia syndrome. She had imparied cellular immune response to herpes simplex virus and developed no antibodies against the virus. To our knowledge, this is the first fatal case of disseminated herpes simplex virus infection in ataxiatelangiectasia.
References
Jun 21, 1976·JAMA : the Journal of the American Medical Association·E J YoungJ F Greene
Mar 19, 1970·The New England Journal of Medicine·A J Nahmias
Jan 1, 1968·American Journal of Diseases of Children·W B BeckerD McKenzie
Jan 1, 1969·Journal of Clinical Pathology·T H FlewettW M Philip
Sep 27, 1973·The New England Journal of Medicine·A J Nahmias, B Roizman
Jul 1, 1974·Human Pathology·J M OrensteinS L Wilens
Jan 1, 1972·The American Journal of Medicine·S A MullerR K Winkelmann
Jun 1, 1972·Human Pathology·J C Lee, I E Fortuny
Jul 1, 1972·Medicine·D E McFarlinT A Waldmann
Mar 1, 1970·The Journal of Pediatrics·D R MillerJ V Hnilicka
Apr 18, 1970·British Medical Journal·B E Juel-Jensen
Oct 1, 1968·Physical Therapy·R L Arledge
Oct 1, 1968·Journal of Neuropathology and Experimental Neurology·M J AguilarR P Sedgwick
Sep 1, 1966·The American Journal of Medicine·R D PetersonR A Good
May 30, 1964·Lancet·R D PETERSONR A GOOD
May 30, 1964·Lancet·P FIREMAND GITLIN
Apr 1, 1952·A.M.A. American Journal of Diseases of Children·W W ZUELZER, C S STULBERG
Citations
Apr 1, 1985·Journal of the American Academy of Dermatology·L L Smith, S L Conerly
Sep 15, 2000·Infectious Disease Clinics of North America·J D Fingeroth
Sep 10, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liora HarelJacob Amir
Dec 4, 2009·Journal of Pediatric Hematology/oncology·Dirk HolzingerAndreas H Groll
May 24, 2015·Virology·Joseph M KulinskiVera L Tarakanova
Apr 8, 2004·The Journal of Pediatrics·Anna Nowak-WegrzynHoward M Lederman
Jul 14, 2017·Journal of Virology·Eric J DarrahVera L Tarakanova
Jul 22, 2017·Virology·Eric J DarrahVera L Tarakanova