PMID: 7538574May 1, 1995Paper

Disseminated intravascular coagulation associated with granulocyte colony-stimulating factor therapy in a child with human immunodeficiency virus infection

The Journal of Pediatrics
B U MuellerM Horne

Abstract

We report a case of disseminated intravascular coagulopathy, apparently caused by exposure to granulocyte colony-stimulating factor (G-CSF). The medical records of patients treated for more than 30 consecutive days with subcutaneously administered G-CSF were reviewed for the occurrence of thrombocytopenia or coagulation abnormalities. New-onset thrombocytopenia with a platelet count less than 100 x 10(9) cells/L (< 100,000 cells/mm3) developed in 9 of 23 patients (39%) after a median of 11 weeks of treatment with G-CSF at dosages between 1 and 10 micrograms/kg per day.

References

Jun 15, 1992·Annals of Internal Medicine·J W ParkA P Venook
Jan 1, 1992·Journal of Acquired Immune Deficiency Syndromes : JAIDS·M RigaudM Karpatkin
Feb 1, 1986·Annals of Internal Medicine·A J CohenC M Kessler

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Citations

Jul 1, 1996·The Pediatric Infectious Disease Journal·A S LauM C Yeung

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