Disseminated intravascular coagulation at an early phase of trauma is associated with consumption coagulopathy and excessive fibrinolysis both by plasmin and neutrophil elastase

Surgery
Mineji HayakawaMasahiro Ieko

Abstract

The aims of the present study were to confirm the consumption coagulopathy of disseminated intravascular coagulation with the fibrinolytic phenotype at an early phase of trauma and to test the hypothesis that thrombin-activatable fibrinolysis inhibitor, neutrophil elastase, and plasmin contribute to the increased fibrinolysis of this type of disseminated intravascular coagulation. Furthermore, we hypothesized that disseminated intravascular coagulation at an early phase of trauma progresses dependently to disseminated intravascular coagulation with a thorombotic phenotype from 3 to 5 days after injury. Fifty-seven trauma patients, including 30 patients with disseminated intravascular coagulation and 27 patients without disseminated intravascular coagulation, were studied prospectively. Levels of thrombin-activatable fibrinolysis inhibitor, tissue-type plasminogen activator plasminogen activator inhibitor-1 complex, plasmin alpha2 plasmin inhibitor complex, D-dimer, neutrophil elastase, and fibrin degradation product by neutrophil elastase were measured on days 1, 3, and 5 after trauma. The prothrombin time, fibrinogen, fibrin/fibrinogen degradation product, antithrombin, and lactate also were measured. Independent of the lactat...Continue Reading

References

Jul 1, 1975·The Journal of Clinical Investigation·E F Plow, T S Edgington
Jul 1, 1976·Annals of Surgery·R M HardawayT Meyers
May 1, 1992·Critical Care Medicine·S GandoM Kubota
Mar 1, 1990·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·R Machovich, W G Owen
Oct 12, 2001·JAMA : the Journal of the American Medical Association·F L FerreiraJ L Vincent
Dec 12, 2001·Seminars in Thrombosis and Hemostasis·S Gando
Jun 19, 2003·The Journal of Trauma·Karim BrohiTimothy Coats
Jan 11, 2005·Critical Care Medicine·Tiffany Medlin OsbornLena M Napolitano
May 5, 2005·Journal of Thrombosis and Haemostasis : JTH·A-K OhlinM Hansson
Oct 26, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Takeshi MatsumotoMichio Matsuda
Dec 20, 2007·Critical Care Medicine·Satoshi GandoUNKNOWN Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group
Dec 26, 2007·Critical Care Medicine·R Phillip DellingerUNKNOWN World Federation of Societies of Intensive and Critical Care Medicine
Aug 18, 2009·Transfusion·Nancy M Dunbar, Wayne L Chandler

❮ Previous
Next ❯

Citations

Jul 22, 2014·Critical Care : the Official Journal of the Critical Care Forum·Juan José Egea-GuerreroMaría Dolores Freire-Aragón
Nov 18, 2011·Critical Care : the Official Journal of the Critical Care Forum·Pär I JohanssonSisse R Ostrowski
Mar 14, 2013·Shock·Daniel N DarlingtonMichael A Dubick
Dec 10, 2013·Hematology·Nathan J White
Jan 29, 2013·Anesthesiology Clinics·Oliver M Theusinger, Jerrold H Levy
Jul 17, 2012·Blood Reviews·Nicola S CurrySimon J Stanworth
Dec 26, 2015·Current Opinion in Anaesthesiology·Ross A Davenport, Karim Brohi
Oct 20, 2011·Hämostaseologie·H SchöchlC Solomon
Mar 26, 2013·Journal of Thrombosis and Haemostasis : JTH·S GandoUNKNOWN Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis (ISTH)
Jan 3, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Daijiro TakahashiAkira Shirahata
Dec 3, 2014·Anaesthesia·A Cap, B J Hunt
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Satoshi Gando, Yasuhiro Otomo
Apr 25, 2015·Critical Care : the Official Journal of the Critical Care Forum·Sisse Rye OstrowskiPär Ingemar Johansson
Dec 19, 2014·Blood·Jerrold H Levy, Lawrence T Goodnough
Apr 24, 2016·Free Radical Biology & Medicine·Nathan J WhiteDominic Chung
Oct 7, 2016·Thrombosis Journal·Hidesaku AsakuraUNKNOWN DIC subcommittee of the Japanese Society on Thrombosis and Hemostasis
Mar 23, 2017·The Journal of Trauma and Acute Care Surgery·Nathan J WhiteAndrew P Cap
Jan 26, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Hiromoto MurakamiSubrina Jesmin
Sep 19, 2017·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·D H LeeY S Cho
Dec 15, 2017·Anesthesia and Analgesia·Philipp SteinOliver M Theusinger
Aug 25, 2017·The Journal of Trauma and Acute Care Surgery·Christopher D BarrettMichael B Yaffe
Aug 11, 2018·Critical Care Medicine·Nina BuchteleMichael Schwameis
May 4, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Nathan J WhiteKevin R Ward
Feb 14, 2018·Blood Advances·Samantha J MontagueElizabeth E Gardiner
Sep 10, 2019·Anesthesiology and Pain Medicine·Fatemeh Javaherforoosh ZadehMansoor Soltanzadeh
Aug 24, 2012·Current Opinion in Critical Care·Oliver M TheusingerDonat R Spahn
Aug 25, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mineji HayakwaMasahiro Ieko
May 10, 2017·Internal and Emergency Medicine·Stefano GiordanoPaolo Simioni
Sep 15, 2018·Anesthesiology and Pain Medicine·Farahzad JanatmakanSheida Nassajian
Sep 27, 2012·Current Opinion in Critical Care·Daniel Frith, Karim Brohi
Nov 23, 2019·Anesthesiology and Pain Medicine·Fatemeh Javaherforoosh ZadehMaryam Zamankhani
Oct 24, 2014·Current Opinion in Critical Care·Andrew Cap, Beverley Hunt
Mar 29, 2021·Journal of Thrombosis and Haemostasis : JTH·Alexander St JohnJosé López

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.