Disseminated mucormycosis associated with invasive pulmonary aspergillosis in a patient treated for post-transplant high-grade non-Hodgkin's lymphoma

Leukemia & Lymphoma
Nicolas BlinPhilippe Moreau

Abstract

The incidence of mucormycosis, defined as systemic infection caused by fungi of the class Phycomycetes has been increasing over the past 2 decades, especially in profoundly immunocompromised hosts. We report a new case in a patient presenting with post-transplant high-grade non-Hodgkin's lymphoma who received a prolonged treatment with voriconazole and caspofungin for an invasive pulmonary aspergillosis. Definite diagnosis of mucormycosis was made by liver biopsy of nodules mimicking progressive lymphoma. The patient died 1 week after the diagnosis of mucormycosis despite the administration of liposomal amphotericin B. The role of voriconazole and caspofungin in the emergence of mucormycosis is discussed.

References

Aug 9, 2002·The New England Journal of Medicine·Raoul HerbrechtUNKNOWN Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillu
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John R PerfectElizabeth Johnson
Oct 11, 2003·Lancet·David W Denning
Feb 27, 2004·The New England Journal of Medicine·Francisco M MartyLindsey R Baden

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Citations

May 26, 2009·Revista iberoamericana de micología·Miguel Salavert-Lletí, Rafael Zaragoza-Crespo
Jul 16, 2005·Clinical Microbiology Reviews·Brad SpellbergAshraf Ibrahim
Mar 25, 2008·Therapeutics and Clinical Risk Management·Javier PemánMiguel Gobernado
Mar 25, 2008·Therapeutics and Clinical Risk Management·Gregory EschenauerPeggy L Carver
Oct 1, 2009·Emerging Infectious Diseases·Dounia BitarOlivier Lortholary
Apr 28, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S PadmanabhanN G Almyroudis
Aug 21, 2013·Veterinary Microbiology·Juliana Simoni Moraes TondoloJanio Morais Santurio
Apr 16, 2013·Revista iberoamericana de micología·Juan Carlos Pozo-LaderasMaría José Linares-Sicilia
Dec 30, 2014·Revista iberoamericana de micología·Juan Carlos Pozo LaderasMaría José Linares Sicilia

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