Disseminated Mycobacterium avium complex: correlation between blood and tissue burden

The Journal of Infectious Diseases
F J TorrianiD Havlir

Abstract

To determine the relationship between levels of Mycobacterium avium complex (MAC) in blood and tissues, histopathologic examination and quantitative MAC cultures were done on blood samples and tissue samples of 7 organs at autopsy of 10 AIDS patients who had been treated for MAC bacteremia. Blood and tissue cultures were negative for MAC for 3 of the patients and positive for 7. The numbers of MAC colony-forming units in the blood and tissues were highly correlated. The highest concentrations of MAC were observed in the reticuloendothelial organs, with a maximum of 6.9 log10 cfu/g in mesenteric lymph nodes and 6.8 log10 cfu/g in spleen. Histopathologic findings paralleled quantitative cultures and were consistent with entry of MAC via lymphatics through the gastrointestinal tract, followed by hematogenous dissemination.

Citations

Jun 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Judith A AbergJudith S Currier
Apr 30, 2011·Future Microbiology·Devyani Deshpande, Tawanda Gumbo
Apr 29, 2015·Infectious Diseases·Sheng BiJi-Fang Sheng
Oct 14, 2011·Comparative Immunology, Microbiology and Infectious Diseases·Kenji HibiyaJiro Fujita
Dec 2, 1998·Clinical Radiology·L Pantongrag-BrownA E Brown
Jan 3, 2012·Tuberculosis·Joseph O FalkinhamRichard D Gandour
Apr 1, 1999·The Journal of Infectious Diseases·C R Horsburgh

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