Disseminated Mycobacterium genavense infection in a healthy boy

Human Pathology
Hiroaki MiyoshiRyuichi Wada

Abstract

Mycobacterium genavense (M genavense) has been recognized as a life-threatening pathogen in severely immunocompromised patients. To our knowledge, disseminated M genavense infection has never been described in immunocompetent individuals. Here, we report a case of disseminated M genavense infection in a healthy Japanese boy. A 15-year-old boy who had never been diagnosed with an immunodeficiency disorder was hospitalized because of ileus. Tumorous lesions were identified in the ileum, cecum, and ascending colon, resulting in stenosis of ileocecal valve. There was diffuse proliferation of histiocytes throughout the intestinal wall, along with lymphocytic infiltration. No nuclear or cellular atypia was present in these cells. Ziehl-Neelsen staining revealed numerous acid-fast bacteria in histiocytes. After surgery, systemic lymph node swelling was noticed by generalized examination, including the mesenteric and cervical lymph nodes. M genavense DNA was identified by direct sequencing of 16S ribosomal DNA that had been amplified by polymerase chain reaction.

References

Mar 1, 1996·The Pediatric Infectious Disease Journal·V LiberekC A Siegrist
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C BogdanW Solbach
Jun 25, 1999·Scandinavian Journal of Infectious Diseases·M E Hillebrand-HaverkortJ H Ten Veen
Feb 9, 2008·Emerging Infectious Diseases·Victoire de LastoursIsabelle Podglajen

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Citations

Jan 17, 2012·The Veterinary Clinics of North America. Exotic Animal Practice·Jennifer Buur, Miguel D Saggese
Nov 22, 2017·Infectious Diseases·Maryam MahmoodJohn W Wilson
Sep 20, 2019·Southern African Journal of HIV Medicine·Pieter EkermansJakko van Ingen
Nov 11, 2015·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Yoshihiko OgawaTakuma Shirasaka

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