Disseminated Mycobacterium gordonae and Mycobacterium mantenii infection with elevated anti-IFN-γ neutralizing autoantibodies

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Isano HaseJakko van Ingen

Abstract

A case of disseminated nontuberculous mycobacteria(l) (NTM) infection in a patient with positive neutralizing anti-interferon-γ (IFN-γ) autoantibodies involving bone, bronchus, systemic lymph nodes, and skin is reported. The causative NTMs were two different strains: Mycobacterium gordonae, which rarely causes true disease, and Mycobacterium mantenii, which is extremely rare. Anti-mycobacterial treatment successfully ameliorated all disseminated lesions. Although the concentration of anti-IFN-γ autoantibodies increased during the pre-treatment period, it gradually decreased after anti-mycobacterial treatment was started.

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Citations

Apr 22, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Isabelle SuárezJan Rybniker
Nov 11, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ami AokiToshiaki Kikuchi
Sep 25, 2019·The American Journal of Tropical Medicine and Hygiene·Eriko KashiharaHiroshi Koyama
Aug 21, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gloria H HongSteven M Holland
Jan 29, 2019·Journal of Immunology Research·Ploenchan ChetchotisakdGanjana Lertmemongkolchai
Dec 20, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Kai Ling ChinArmando Acosta
Jan 13, 2021·Experimental Biology and Medicine·Kriangkrai ChawansuntatiJiraprapa Wipasa

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