Disseminated Mycobacterium kansasii infection associated with skin lesions: a case report and comprehensive review of the literature.

Journal of Korean Medical Science
Sang Hoon HanJune Myung Kim

Abstract

Mycobacteruim kansasii occasionally causes disseminated infection with poor outcome in immunocompromised patients. We report the first case of disseminated M. kansasii infection associated with multiple skin lesions in a 48-yr-old male with myelodysplastic syndrome. The patient continuously had taken glucocorticoid during 21 months and had multiple skin lesions developed before 9 months without complete resolution until admission. Skin and mediastinoscopic paratracheal lymph node (LN) biopsies showed necrotizing granuloma with many acid-fast bacilli. M. kansasii was cultured from skin, sputum, and paratracheal LNs. The patient had been treated successfully with isoniazid, rifampin, ethmabutol, and clarithromycin, but died due to small bowel obstruction. Our case emphasizes that chronic skin lesions can lead to severe, disseminated M. kansasii infection in an immunocompromised patient. All available cases of disseminated M. kansasii infection in non HIV-infected patients reported since 1953 are comprehensively reviewed.

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Citations

Aug 12, 2014·Skeletal Radiology·Raj SinhaAlvin Karsandas
Apr 24, 2012·Enfermedades infecciosas y microbiología clínica·Dorcas Cajigas-PezoZaida Rentero-Martínez
Apr 7, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·P KaurC N Kotton
Jul 25, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J-H ChoY-L Kim
Jul 3, 2013·Veterinary Clinical Pathology·Atsuko MuraiMasashi Yuki
Sep 9, 2016·Annals of the American Thoracic Society·Jana P LovellSteven M Holland
Jun 18, 2014·Anais Brasileiros De Dermatologia·Catarina Tenório de Lima, Vera Magalhães
Aug 21, 2014·Journal of Leukocyte Biology·Chia-Chen LuHsin-Chih Lai
Feb 27, 2019·American Journal of Clinical Dermatology·Khatiya ChelidzeEsther Ellen Freeman
Dec 30, 2016·Oxford Medical Case Reports·Tarek TurkKhulood Raslan
Nov 22, 2020·Pathogens·Petra ČernáDanièlle A Gunn-Moore
Sep 13, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Arisa YamadaAkihiko Gotoh
Jul 15, 2021·Journal of Avian Medicine and Surgery·Abigail DuvallLinden Craig

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Methods Mentioned

BETA
MDS
biopsy
ESR

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