PMID: 9542599May 30, 1998Paper

Disseminated perivenous necrotizing encephalomyelitis in systemic lupus erythematosus: report of an autopsy case

Acta Neuropathologica
M Shintaku, R Matsumoto

Abstract

The patient, a 22-year-old woman who had been treated for systemic lupus erythematosus (SLE) for 10 years, was hospitalized for arthralgia, melena, and difficulty in walking. CT examination of the brain showed grain-like high-density lesions scattered throughout the cerebral white matter and basal ganglia. At autopsy, multiple perivenous, well-demarcated foci of brownish discoloration were seen scattered throughout the cerebral white matter and basal ganglia. Histopathologically these lesions consisted of foci of coagulation necrosis surrounding the veins. The veins in the foci showed fibrous thickening of the walls, but there were no indications of vasculitis. At the periphery of the lesions, the axons were better preserved than their myelin sheaths. The neuropathological findings in the present case closely resemble those of acute disseminated (perivenous) encephalomyelitis, although an inflammatory cell infiltration had apparently already subsided. Although its pathogenesis remains unclear, this finding should not be regarded as an incidental complication but rather as a rare subtype of central nervous system lesion occurring with SLE.

Citations

Apr 22, 2008·Journal of Neurology·Pedro Emilio BermejoCarlos Escamilla
Apr 8, 2014·Neurología : publicación oficial de la Sociedad Española de Neurología·M C Gil AlzuetaM T Cabada Giadás
Nov 3, 2009·Seminars in Arthritis and Rheumatism·Wilmer L SibbittCarlos A Roldan
Oct 7, 2004·Journal of the Neurological Sciences·Hiroo IchikawaImaharu Nakano
Jul 6, 2004·Clinics in Dermatology·Kenneth T Calamia, Maria Balabanova
Oct 19, 1999·Arthritis and Rheumatism·W L SibbittW M Brooks

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.