Disseminated Pneumocystosis in a Toy Poodle

Journal of Comparative Pathology
T SakashitaR Yamaguchi

Abstract

A 1-year and 7-months-old neutered male toy poodle was presented with persistent respiratory distress, gradual weight loss and melaena. Thoracic radiography showed an unstructured interstitial lung pattern. Histopathological examination of tissues collected at necropsy examination revealed disseminated infection by Pneumocystis carinii. The organisms were detected in the lungs, lymph nodes, liver, heart, kidneys, spleen, gastrointestinal tract and pancreas. In the lungs, the organisms were present in the alveolar space and interstitial tissue, and calcified foci containing P. carinii were observed. The presence of the organism in non-thoracic lymph nodes provided evidence of lymphogenous spread. A definitive diagnosis of disseminated pneumocystosis was achieved through the use of Grocott methenamine silver staining, immunohistochemistry (IHC) and polymerase chain reaction for P. carinii. Depletion of cells expressing immunoglobulin (Ig)A and IgG was confirmed by IHC of lymphoid tissue, suggesting possible underlying immunodeficiency.

References

Nov 22, 1990·The New England Journal of Medicine·UNKNOWN National Institutes of Health-University of California Expert Panel for Corticosteroids as Adjunctive Therapy for Pneumocyst
Nov 1, 1990·Reviews of Infectious Diseases·M C Raviglione
Jun 1, 1996·The Journal of Small Animal Practice·R G LobettiJ A Spencer
Jul 1, 1997·Clinical Microbiology Reviews·V L NgW K Hadley
Nov 24, 1999·Veterinary Pathology·M F Perron LepageM M Suter
Feb 26, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·R Lobetti
Apr 20, 2001·The Journal of Veterinary Medical Science·Y HagiwaraH Tsujimoto
Jan 8, 2013·The Journal of Veterinary Medical Science·Michiko SakakibaraShinichi Hatama
Feb 27, 2015·The Journal of Veterinary Medical Science·Hideyuki KanemotoHiroyuki Nakayama
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
May 27, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Christiane Weissenbacher-LangFrank Künzel
Nov 18, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Christiane Weissenbacher-LangFrank Künzel

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Citations

Dec 5, 2020·Journal of Veterinary Internal Medicine·Kristen MerrillCarol Reinero

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