Disseminated reticulate hypomelanosis developing during primary biliary cirrhosis

Dermatology : International Journal for Clinical and Investigative Dermatology
R VirabenB Gorguet

Abstract

We report on a 50-year-old woman with disseminated reticulate hypomelanosis developing on the limbs and abdomen during primary biliary cirrhosis (PBC). Histopathological examination showed vacuolar basal cells, dyskeratosis and large multinucleated epidermal cells. Diagnosis of lichen sclerosus et atrophicus and autoimmune disease are discussed. The similarity between cutaneous changes in PBC and a graft-versus-host reaction is outlined.

Citations

Oct 11, 2017·Clinical Reviews in Allergy & Immunology·Benedetta Terziroli Beretta-PiccoliCarlo Mainetti

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